Two related "wild" ideas, as I think we probably have the basic technology and knowledge but probably not something we can quite do now.

My understanding is that the virus is attacking the ACE2 molecules. These actually form a gateway between the interior of the cell and the external environment.

If so, in theory, we might be able to create a number of artificial "bodies" -- thinking just a lipid bilayer sack with some ACE2 elements attached. Any virus that binds with that will "infect" the dummy cell but have no way of replica... (read more)

1leggi13dThis is very interesting information. I was wondering (but not enough to actually research it) why diabetes mellitus (DM) was a bigger risk factor of severe disease than I would have associated with the "normal" increased risk with infections in patients with DM. A quick search led me to this article in the Lancet. [https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(20)30116-8/fulltext]

I believe there was also an issue related to glucose levels as well, which then results in worse infection outcomes with this virus.

I just came across the following that might be of interest as well: https://www.eurekalert.org/pub_releases/2020-02/msa-arc022620.php

That was from late February and I've not seen anything providing any update on the trials they were starting.

Not sure if that is working as I was thinking, a decoy to get the virus to bind with something other then the cell and so neutralizing it.

March Coronavirus Open Thread

by Elizabeth 1 min read8th Mar 2020374 comments

58


This thread was created on 3/8/2020, or approximately one million years ago in virus time. It’s getting pretty bloated now, and a lot of things that were high value at the time have been eclipsed by events, making karma not a very useful sorting tool. So I’m declaring this thread finished, and asking everyone to move over to the April Coronavirus Open Thread.

Interested in what happened in this thread? Here’s the timeless or not-yet-eclipsed highlights:

  • Scott Alexander comes up with Hammer and Dance 6 days before Tomas Pueyo
  • Spiracular on why SARS-Cov-2 is unlikely to be lab-created.
  • Two documents collating estimates of basic epidemiological parameters, in response to this thread
  • Discussion on whether the tuberculosis vaccine provides protection against COVID-19.
  • Suggestive evidence that COVID-19 removes sense of taste and smell.
  • Could copper tape be net harmful?