I think this paper implies that rare harmful genetic mutations explains lots of the variation in human intelligence. Since it will soon be easy for CRISPR to eliminate such mutations in embryos, I think this paper's results if true means that genetic engineering for super-intelligence will be relatively easy.

I don't think that this shows anything different from earlier studies, which it shouldn't because it doesn't use different methods.* I guess it simultaneously measures that 25% of the variance is due to common variants and another 25% is due to rare variants in LD with common variants, while previously those results came from separate studies.

I have only skimmed the paper, but I reject the claim in the abstract that these "rare" variants are due to mutation-selection balance (aka mutational load). That is the claim you are talking about, right? T... (read more)

Open thread, Feb. 06 - Feb. 12, 2017

by MrMind 1 min read6th Feb 2017115 comments


If it's worth saying, but not worth its own post, then it goes here.

Notes for future OT posters:

1. Please add the 'open_thread' tag.

2. Check if there is an active Open Thread before posting a new one. (Immediately before; refresh the list-of-threads page before posting.)

3. Open Threads should start on Monday, and end on Sunday.

4. Unflag the two options "Notify me of new top level comments on this article" and "