I have only skimmed the paper, but I reject the claim in the abstract that these "rare" variants are due to mutation-selection balance (aka mutational load). That is the claim you are talking about, right?

Yes

Having a choice between targeting common variants and rare variants can only make things easier than not having a choice, but why do you think rare variants are easier?

Eliminating rare variants almost certainly won't have negative side effects. If X and Y reduce my intelligence and X is a rare variant and Y a common one, then there is a much bigger chance that Y does something good for me than that X does.

Do you really expect that to be easy soon?

If we have solid evidence that CRISPR editing could result in super-geniuses I expect lots of resources (perhaps in China) to be devoted to the relevant practical problems.

Yes, super-rare variants have some advantages, but as I said, common variants have other advantages. It sounds to me that you have fixated on one approach, rather than considering tradeoffs. For that matter, consider the option of cloning, a mere engineering problem. It won't get you "super-geniuses," but that is an arbitrary threshold. It seems to me that you have imposed multiple arbitrary thresholds to isolate this one path.

Open thread, Feb. 06 - Feb. 12, 2017

by MrMind 1 min read6th Feb 2017115 comments

5


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