I think it would be possible to dump the mystical elements of Buddhism, and combine the rest with Bayesianism. I could see the ideal of optimal enlightenment.
I see some very promising trends in some of the Western Zen stuff, eg Brad Warner ( http://hardcorezen.blogspot.com/)(before anyone says it, I also see big problems with him!)
There's a lot of dumping of mysticism, and some of the more unfortunate bits like gods and reincarnation.
And there are Buddha quotes like:
"Be lamps unto yourselves.
Be refuges unto yourselves.
Take yourself no external refuge.
Hold fast to the truth as a lamp.
Hold fast to the truth as a refuge. "
(intermediate source http://www.sapphyr.net/buddhist/buddhist-quotes.htm, I'm p... (read more)