It says: 14.2 out of 100 men of European ethnicity who share Robin Powell's genotype will develop Alzheimer's Disease between the ages of 50 and 79.

Apparently, according to 23andMe, the normal incidence in european men in that age range is 7.2%, so it's "only" twice as likely.

In that case, your current age matters a lot. If you are substantially below that age then there's a high likelyhood that before you hit that age range we will have some effective treatments for Alzheimer's (although I think people are generally overly optimistic about a lot of the current treatment suggestions).

3gwern8ySo your 14% is for a range that overlaps with a 19% range... Might want to investigate your risk a little more carefully, eg. what's your total lifetime risk with that info compared with the base-rate lifetime risk for people with your life expectancy?

What deserves cryocide?

by rlpowell 1 min read19th Apr 201239 comments


So being signed up for cryonics shifts my views on life and death, as might be expected.

In particular, it focuses my views of success on the preservation of my brain (everything else too, just in case, but especially the brain).  This means, obviously, not just the lump of meat but also the information within it.

If I'm suffering a degenerative disease to that meat or its information, I'm going to want to cryocide to preserve the information (and the idea of living through slow brain death doesn't thrill me regardless).

What I don't know is: given the current state of science, what sorts of things do I need to be worried about?

In particular, I'm wondering about Alzheimer's; does it appear to be damage to the information, or to the retrieval mechanism?

But any other such diseases interest me in this context.