Overcomingbias and Lesswrong have seen considerable discussion of several key aspects of the world that do not directly bear on rationality (listed as question-headings, below). These discussions are interesting in two lights.
Robin Hanson has argued strongly that it does not, and that a vast chunk of America's national economy is being wasted. Many commenters have disagreed, agreed, or cited research in support of more nuanced positions. You can read the details in Robin Hanson's posts, and the ensuing comments threads:
If your goal is income, and if you can get in, then, yes, you should. Hanson reviews the data here.
Eliezer Yudkowsky and Robin Hanson argue that cryonics is a good deal; it offers a non-negligible chance at a much longer life, at a price where, if the chance came labeled "experimental cure for cancer" rather than "experimental cure for apparent death", many would take it.
Relevant blog posts on cryonics.