i would not only pay a lot per flight for good wifi, i would also fly way more often
I'm not sure how common this preference is.
I think that the economic gains from people traveling on business having access to better wifi on planes might be quite large[1], but airlines themselves are not well-positioned to capture very much of those gains. There are a very small number of domestic airlines which don't offer any wifi on their planes at all. The rest generally offer it for free, or for some relatively low price (on the order of $10). Often even the airlines that charge for it offer it as a free or discounted perk for their "frequent fliers". Those airlines might have a hard time increasing the sticker price of their wifi offering, even if the quality improves a lot, so they'd have to hope for most of the gains to come from business-class travelers switching to them from a competitor (or, as in your case, deciding to fly at all, on the margin). But it's not obvious to me that most business-class travelers themselves want better wifi, since once it improves past a certain point they might have very little excuse for not working through the flight. (Maybe this is too cynical, or already moot, idk.)
None of this is meant to say that airlines have no incentive to improve their wifi - I'm pretty sure some of them are already getting started on the Starlink transition - merely that there are a bunch of factors that might make that incentive weaker than it might obviously seem.
Maybe a sizable fraction of "the economic value of their average working hour * flight duration", which could be thousands of dollars per flight for some travelers.
Hm, no, I didn't change anything. The section headings are meant to indicate which transmission method those studies decided was substantially responsible for spreading colds.
@bhauth emphasizes the difficulty of studying transmission of "colds" because there are over 200 different virus strains responsible for what we consider "a cold", in response to my recent post.
I want to dig into the question of feasibility a bit more:
But it's not feasible to do human studies of so many virus types - consider how hard it was for society just to realize that COVID was transmitted via aerosols!
Ok, but why isn't this feasible? Certainly it's the case that nobody has tried, but I don't think it'd be prohibitively expensive, at least on the scale of medical research.
Some quick back-of-the-envelope math...
How much would it cost to find and pay qualified volunteers for challenge trial like Dick et al., 1987 today? My guess is that this is doable for $7k per volunteer[1].
How many volunteers would we need? In the pessimal case - the one where we're actually just going to test every single virus strain separately, rather than doing something more sensible[2]...
My off-the-cuff guess is that 300 volunteers per virus would be enough to draw quite strong conclusions, with good experiment design[3].
That's 60k volunteers, for a $420m price tag, not including other study costs.
Housing, feeding, and otherwise taking care of each participant - idk, let's be conservative, and call it $300/participant-day? If we're going with ten days per participant that's $300 * (60k * 10) = $180m.
Clinical staff costs - conservatively, 2-3 hours per day per participant, but mostly not the super-expensive PI time, but mostly RNs/coordinators/etc. Maybe $250/participant-day? $250 * (60k * 10) = $150m.
Lab work costs - I think you get a lot of benefits of scale, here, but let's say $2k/participant, so $120m.
I have no idea how to get accurate numbers for how much it'd cost to manufacture enough GMP-grade virus stock for each virus; LLMs converge on a $1-5m range per virus. Unfortunate, but even at the top end, that's $1.5b.
$420m + $180m + $150m + $120m + $1.5b = $2.37b.
And this is the dumb brute-force solution! Now, maybe it actually turns out that they're all different and nothing generalizes, so that mechanistic investigations into figuring out if we can predict a given virus's transmission methods without running a full human challenge trial on it, say by looking at its physical features, just doesn't work. I still think that a sane civilization smashes that button for a couple billion dollars. Are there higher priorities? Sure, we should do those too.
A COVID challenge trial paid volunteers $6200 in mid-2021, but the viruses we'd be testing are in-expectation substantially less harmful and unpleasant than COVID, especially the variants that existed at the time. Some of the difference will be eaten up by sourcing costs, though.
Like testing a smaller number, looking at those results, coming up with mechanistic hypotheses that try to explain why [virus x] spreads effectively by transmission method [y] but not [z], ideally ones where we can try to falsify them more cheaply than running a full human challenge trial, and repeating until we actually understand how particular viruses spread (to the point where we can make reasonably accurate predictions about future viruses based purely on their physical characteristics, or other easily-testable traits), rather than just knowing the mere fact of their propensity to spread via some method.
Though I'm not sure how establishment-compatible it is.
Yep, that is a big question mark that I note in the conclusion:
Might depend on details of specific viruses, and I don't think we've done enough research to have meaningful evidence about whether different RVs have very different transmission profiles from each other.
(And also implicitly in a few places within the body of the post.)
I think it'd be reasonable to apply a large discount to any updates you'd otherwise make on the question of rhinovirus transmission from this post, at least absent a follow-up investigation re: whether they behave similarly or not.
The humidity thing is a good catch. I think there might've been one or two studies which investigated some related questions and reported some information about humidity, but I didn't go very deep on them. Maybe a mistake!
Though also hard to square that with dry winter conditions being prime cold and flu season.
Yeah, that's an interesting consideration which came up in discussion with someone yesterday. Another possibility is that people congregate indoors more during wintertime, but I haven't looked into that specific question. (It wouldn't surprise me if someone had looked into it during COVID.)
I could also imagine it being the case that viruses are much less likely to be transferred from one patch of dry skin to another patch of dry skin via normal contact, than they are to be picked up by whatever mechanisms are used in various studies to check for the "presence" of viruses on surfaces. In several cases, this was approximately "dip fingers into some kind of liquid solution, then culture whatever was picked up in that solution".
Unfortunately, the disinfectant results from Gwaltney & Hendley, 1982 point in the opposite direction:
Spraying of contaminated tiles with a commercially available phenol/alcohol disinfectant reduced (p = 0.003) the rate of recovery of virus from the tiles from 42% (20/47) to 8% (2/26). Similarly, the rate of detection of virus on fingers touching the tiles was reduced (p = 0.001) from 61% (28/46) with unsprayed tiles to 21% (11/53) with sprayed tiles. Fifty-six per cent (9/16) of the recipients exposed on three consecutive days to untreated tiles became infected while 35% (7/20) touching only sprayed tiles became infected with rhinovirus (p = 0.3).
The reduction in lab detection of viruses from the plastic tiles after being sprayed with a disinfectant (and then left to dry for 10 minutes) was much larger than the reduction in people getting sick after rubbing their fingers on the disinfected tiles (vs. non-disinfected tiles), and then rubbing their eyes/nose.
I expect this sort of thing to be quite sensitive to object-level details, and the sample sizes here aren't huge.
Now, you might think "Why not bring the deadline back to like 8pm, so that people have the night off?". But that's kind of antithetical to what Inkhaven is here to offer. Should I just cut out 4 hours of their day where they can't write? I assure you, they wouldn't spend the late hours precociously working on tomorrow's stuff. They selected into being the kind of people who needed an externally imposed deadline to get stuff done. They'd just be losing a good chunk of writing each day.
I'm not observing the residents very closely, but I tentatively roll to disbelieve that most of the residents who are publishing last-minute are making full use of the day to write. My guess is that having e.g. a 10 pm deadline wouldn't reduce "active writing time" by anything like 2 hours for most residents; they would simply "get down to business" earlier in the day. Someone mentioned that this would substantially reduce the amount of time that residents have to integrate feedback from the feedback circles, which happen right before dinner. That seems true and somewhat difficult to avoid given the current structure. I still think that forcing the last-minute writing to happen two hours earlier has a lot of benefits: residents are less tired when they're doing their last minute writing & editing, and they have more time to socialize, unwind, and spend some time doing less "pressured" research/writing/ideating/etc.
Another meta line of argument is to consider how many people have strongly held, but mutually incompatible philosophical positions.
I've been banging my head against figuring out why this line of argument doesn't seem convincing to many people for at least a couple of years. I think, ultimately, it's probably because it feels defeatable by plans like "we will make AIs solve alignment for us, and solving alignment includes solving metaphilosophy & then object-level philosophy". I think those plans are doomed in a pretty fundamental sense, but if you don't think that, then they defeat many possible objections, including this one.
As they say: Everyone who is hopeful has their own reason for hope. Everyone who is doomful[1]...
In fact it's not clear to me. I think there's less variation, but still a fair bit.
It can vary enormously based on risk factors, choice of car, and quantity of coverage, but that does still sound extremely high to me. I think even if you're a 25-yo male with pretty generous coverage above minimum liability, you probably won't be paying more than ~$300/mo unless you have recent accidents on your record. Gas costs obviously scale ~linearly with miles driven, but even if your daily commute is a 40 mile round-trip, that's still only like $200/mo. (There are people with longer commutes than that, but not ones that you can easily substitute for with an e-bike; even 20 miles each way seems like a stretch.)
The link to Supervising strong learners by amplifying weak experts is in the following sentence:
This is the very first sentence in the
Iterated distillation and amplification (IDA)collapsible section, and is clearly not being offered as evidence that is meant to justify extrapolating to the very last sentence in that section:The rest of your post has a lot of other objections that seem invalid or confused, like attempting to use the lack of the paper's peer review as meaningful evidence about whether a technique like that might generalize or not, but I don't think it's worth getting into them because the entire argument is premised on a misunderstanding of what evidence is being offered for what purpose.