LinkSummaryDate AddedLast UpdatedName / Opening Sentence
5
research.fhcrc.org Academic
Great explanation of C19's form and lifecycle, including explanations of how certain potential treatments could work
Great explanation of C19's form and lifecycle, including explanations of how certain potential treatments could workMar 20???
The last pandemic, the one before that, and this one
5
sciencedirect.com Academic
An overview of the coronavirus family, including physical form, pathogenicity, and epidemiology
An overview of the coronavirus family, including physical form, pathogenicity, and epidemiologyMar 18Jan 1
Medical Microbiology Chapter 57: Coronaviruses
5An overview of the coronavirus family, including physical form, pathogenicity, and epidemiologyAn overview of the coronavirus family, including physical form, pathogenicity, and epidemiologyMar 18Jan 1
Coronaviruses: An Overview of Their Replication and Pathogenesis
4
docs.google.com Discussion
Introduction to various categories and molecular methods for diagnosing COVID19, outline companies and academic groups developing diagnostics
Introduction to various categories and molecular methods for diagnosing COVID19, outline companies and academic groups developing diagnosticsMar 19Mar 17
COVID19 Molecular Diagnostics Briefing
3
gisaid.org Academic (pre-print)
Showing lots of samples of genomic data gathered during the C19 outbreak, and a tree with the history of changes.
Showing lots of samples of genomic data gathered during the C19 outbreak, and a tree with the history of changes.Mar 26Mar 26
Genomic epidemiology of hCoV-19
3Brief investigation by unknown authors that suggests that there might be some protective effect of the BCG vaccine (a common tubercolosis vaccine) Brief investigation by unknown authors that suggests that there might be some protective effect of the BCG vaccine (a common tubercolosis vaccine) Mar 26Mar 26
Current Research into Potential of BCG Vaccine to Mitigate COVID-19
3
theatlantic.com News
Layman-accessible description of why C19 is so infectious and so dangerous.
Layman-accessible description of why C19 is so infectious and so dangerous.(EV)Mar 23Mar 20
Why the Coronavirus Has Been So Successful
3
docs.google.com Citizen
An "Explain it to me like I'm 5" for how lungs should work and how C19 interferes with them.
An "Explain it to me like I'm 5" for how lungs should work and how C19 interferes with them.(EV)Mar 22Mar 20
Simple language exploration of COVID-19 ARDS (the very bad lung thing)
3
thelancet.com Academic (pre-print)
Accumulating evidence suggests that a subgroup of patients with severe COVID-19 might have a cytokine storm syndrome. They recommend identification and treatment of hyperinflammation using existing, approved therapies with proven safety profiles to address the immediate need to reduce the rising mortality.
Accumulating evidence suggests that a subgroup of patients with severe COVID-19 might have a cytokine storm syndrome. They recommend identification and treatment of hyperinflammation using existing, approved therapies with proven safety profiles to address the immediate need to reduce the rising mortality.(EV): this would be what made the 1918 flu so bad, and in particular made it kill off the young and healthy faster than the old, which is not what is happening hereMar 18Mar 16
COVID-19: consider cytokine storm syndromes and immunosuppression
Found via facebook.com
3
biorxiv.org Academic (pre-print)
Scientists testesd C19 M-pro protease to determine its preferences, using a large number of both natural and unnatural amino acides.
Scientists testesd C19 M-pro protease to determine its preferences, using a large number of both natural and unnatural amino acides.Mar 17Mar 7
Substrate specificity profiling of SARS-CoV-2 Mpro protease provides basis for anti-COVID-19 drug design
3Reviews what can be deduced about the origin and early evolution of SARS-CoV-2 from the comparative analysis of available genome sequence data. In particular, it offers a perspective on the notable features in the SARS-CoV-2 genome and discusses scenarios by which these features could have arisen.Reviews what can be deduced about the origin and early evolution of SARS-CoV-2 from the comparative analysis of available genome sequence data. In particular, it offers a perspective on the notable features in the SARS-CoV-2 genome and discusses scenarios by which these features could have arisen.Mar 17Feb 16
The Proximal Origin of SARS-CoV-2
Found via lesswrong.com
3David Sinclair suggests that C19 goes creates glycated hemoglobin, based on some of its genes and the drugs that work against itDavid Sinclair suggests that C19 goes creates glycated hemoglobin, based on some of its genes and the drugs that work against itMar 15Mar 14
Since my Harvard lab closed yesterday, I've been reading and interpreting this week's published papers on #COVID19.
Found via twitter.com
3
medrxiv.org Academic (pre-print)
Study of where in the respitory system the virus is found (throat, lungs, stool, but not urine or blood) and can be cultivated from (throat, lungs)
Study of where in the respitory system the virus is found (throat, lungs, stool, but not urine or blood) and can be cultivated from (throat, lungs)(EV) Seems solid but I only read the abstractMar 12Mar 5
Virological assessment of hospitalized cases of coronavirus disease 2019
3
cell.com Academic
Investigation into how SC2 enters the cell and potential targets for intervention
Investigation into how SC2 enters the cell and potential targets for intervention(EV) Pretty good onboarding to why ACE2 is relevantMar 12Mar 5
SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
Found via facebook.com
3Cities that instituted multiple social distancing practices in the 1918 flu had 1/2 the deathsCities that instituted multiple social distancing practices in the 1918 flu had 1/2 the deathsNAMar 12May 1
Public health interventions and epidemic intensity during the 1918 influenza pandemic
2
washingtonpost.com News
WaPo interviews some virologists, who describe SARS-CoV-2's mutation rate as relatively low. This is due to "proofreading machinery". This would imply that a single vaccine would likely suffice, rather than a seasonal one like for influenza.
WaPo interviews some virologists, who describe SARS-CoV-2's mutation rate as relatively low. This is due to "proofreading machinery". This would imply that a single vaccine would likely suffice, rather than a seasonal one like for influenza.(GW) I would like to see a paper, or some numbers, or some more meat here. I understand from other sources that coronaviruses generally have "proofreading machinery" which drives their mutation rate lower than other RNA viruses.Mar 25Mar 24
The coronavirus isn’t mutating quickly, suggesting a vaccine would offer lasting protection
2
assets.publishing.service.gov.uk NGO
The consensus view of the Scientific Pandemic Influenza Group on Modelling. focused on modeling spread and countermeasures
The consensus view of the Scientific Pandemic Influenza Group on Modelling. focused on modeling spread and countermeasuresMar 16Nov 1
SPI-M Modelling Summary