This is my first post on LW so I hope I get it right, please let me know if I don't!
I've been a Geneticist for 15 years (academia and industry) and while there are several issues I feel people aren't addressing with regards to Covid-19, the one that has me most concerned is the digital nature of these new vaccines, over the traditional analog method of letting your body figure out which antibodies it is going to develop on its own. So why is this an issue?
With RNA/DNA vaccines, you are essentially programing a person to have a very specific immunological state. An immunity that is perfectly identical/reproducable between individuals vaccinated against... (read 863 more words →)
>Don't people have different immune systems, thus even if you gave them exactly the same 'bits' that wouldn't result in differing outcomes?
Essentially, there is a region of DNA called the Major histocompatibility complex that is, er, the Genetic equivilent of a computer's PRNG, except it actually does shuffle DNA around (twins aren't even identical), so it's true RNG, but static after conception. This random DNA is used by the immune system to make basically every kind of antigen-receptor possible (the thing that does the sensing/binding for a white blood cell). During development, there is a mechanism by which if antigens match, it's assumed to be matching to "self" and it gets whitelisted... (read 711 more words →)