One of the obstacles I faced when first confronted with the Sequences was figuring out the prerequisites for any given post. At times this is spelled out explicitly, but there are many parallel paths and cross-referencing. Another problem was that posts don't link forward to the posts that reference them.
TrailMeme lets you "blaze a trail" through a mass of blog posts by creating a directed graph, which other users can then "walk." The site is still in Beta, and can be unstable at times.
I tried to more or less follow the posted pre-requisites and link-backs, but culled a lot of the redundant ones to reduce confusion. I found one pre-existing trail, and invite anyone with free time to contribute! Trails so far:
Mysterious Answers to Mysterious Questions
A Human's Guide to Words
Reductionism
Map and Territory
Politics is the Mind-Killer
This implies that the average prior for a medical study is below 5%. Does he make that point in the book? Obviously you shouldn't use a 95% test when your prior is that low, but I don't think most experimenters actually know why a 95% confidence level is used.