Dw629
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Since 1999 there have been "Doogie" mice that were genetically engineered to overexpress NR2B in their brain, and they were found to have significantly greater cognitive function than their normal counterparts, even performing twice as well on one learning test.
No drug AFAIK has been developed that selectively (and safely) enhances NR2B function in the brain, which would best be achieved by a positive allosteric modulator of NR2B, but also no drug company has wanted to or tried to specifically increase general intelligence/IQ in people, and increasing IQ in healthy people is not recognized as treating a disease or even publicly supported.
The drug SAGE718 comes close, but it is a pan-NMDA allosteric... (read 455 more words →)
Yeah unfortunately it seems to be the case that no one has really seriously tried (ie invested a lot of resources, on the scale of a large company or a government) to do R&D on significantly increasing IQ in healthy people through drugs, but I won’t get into that here.
If you’re interested in this area then I really do recommend to talk with the people at Nootopics.
Everychem is the small company that has synthesized most of the drugs I’ve listed and sells them for research (so really they are just research chemicals), but even though this is clearly a grey market, it has attracted…a lot of interest in the community. The user u/sirsadalot is the person who has written the posts I linked and is more knowledgeable than me, so I would suggest talking to him.