Two weeks ago Ben Pace and I asked for practical advice on what to do about coronavirus, with the requirement that advice be justified in some way- ideally full blown models informed by empirical data, but at a minimum, an explanation of why it was helpful. The resulting thread had wonderful advice but makes for, uh, inefficient reading, at best. This post is an attempt to take the best of the Justified Practical Advice Thread and present it in a clear, easy-to-digest format.

It’s important to note that neither the original post nor this one are attempting to give comprehensive advice. If you’re looking for that, I suggest checking out the Guide/FAQs/Intros tab on the LessWrong Coronavirus Link Database. This is for advice that fell through the cracks.

Though I will briefly mention the standard advice. From what I can tell, the most important (and luckily widely publicized advice) is the following:

  • Wash your hands a lot, and wash them to a hospital standard (spend 20 seconds and follow these instructions).
  • Socially isolate yourself, and don't be around other people unless really necessary. Avoid groups of people, especially large gatherings. Really don't go to bars, clubs, restaurants or other places that lots of people pass through (like public transportation).
  • If you are sick, use a mask. They are probably also effective at preventing the disease when you are not sick, but most of the western world currently has massively limited supply, so leave the masks to health workers and sick people.

The rest of this post will summarise the interesting ideas that went beyond these basic recommendations. But if you haven't done (or at least seriously considered doing) all of the above, I would recommend you prioritise the things listed above.

Many of the below recommendations involve buying things. When possible I’ve included a link to a particular amazon page. This is not a strong recommendation for that particular product: it’s an attempt to lower activation energy for acting on a recommendation. If you have reason to believe a particular model is better than what I linked to, please comment and I’ll update if appropriate. Speaking of which, if you think of anything else I missed or got wrong, please comment with that too.

That said, here is the top advice from the Coronavirus Justified Practical Advice thread.

  • Cover your high-touch surfaces with copper tape.
  • Treat newly delivered packages as contagious for 48 hours.
  • Take vitamin D supplements daily.
  • Buy electrolytes to drink if you get ill.
  • Maybe: Buy a pulse oximeter.

Practical Advice

Get 2-inch copper tape and cover high-touch surfaces with it, especially shared high-touch surfaces (Connor Flexman)

This was the clear winner of JPA Olympics– it’s cheap, effective, and very few people had heard of it before. In fact we were hoping for a highly polished, intensely researched post on just this; unfortunately no one has the time right now.

In its place, please enjoy these links:

  • This pre-print showed that this coronavirus in particular had a half life of 2.4-5.11 hours on copper, in contrast to 10.5-16.1 on steel or 13-19.2 on plastic
  • This review showed H1N1 decreased by 4 logs (a factor of 10^4) in 6 hours;
  • This study showed vaccinia and monkeypox viruses reduced by 6 logs (a factor of 10^6) in 3 minutes
  • This study showed murine norovirus was destroyed in 30 minutes, though it doesn't work very well at 4C;
  • This review says that copper oxide filters neutralize all of "bacteriophages [58-62], Infectious Bronchitis Virus [63], Poliovirus [61,64], Junin Virus [59], Herpes Simplex Virus [58,59], Human Immunodeficiency Virus Type 1 (HIV-1) [11,65-67], West Nile Virus [11], Coxsackie Virus Types B2 & B4, Echovirus 4 and Simian Rotavirus SA11 [68]. More recently, the inactivation of Influenza A [55,65], Rhinovirus 2, Yellow Fever, Measles, Respiratory Syncytial Virus, Parainfluenza 3, Punta Toro, Pichinde, Adenovirus Type 1, Cytomegalovirus, and Vaccinia [65]".

Benefits

  • Reduces surface-to-hand-to-face transmission

Costs

  • $11, half an hour to apply tape (this may be a recurring cost, but we don’t know at what interval)
  • Risk of cuts while applying tape (this happened to me once)
  • Risk of cuts from applied tape (0 for me, but other people have reported lots). This is not just a convenience issue- small cuts are breaks in your defenses that microbes can enter.

Why you might not do this

  • You are worried about the risks of exposure to copper
    • You might be are allergic
    • Some people have reported hand irritation and discoloration when they put it on their phones and laptops
    • I poked at this and my takeaway was you’d need to be hooked up to skin infusion IV to get as much copper as you consume via food. Additionally copper IUDs are a common form of birth control, so it can’t be *that* dangerous.
  • You think surface-to-hand-to-face transmission is not significant.
  • You don’t think the results of tests on other viruses apply to coronavirus

The 2’’ is from personal experiences: I got a variety of sizes up to 1’’, and even that was often inconveniently small. I basically never wanted smaller except to patch up gaps, and they’re not so much better than just tearing a small piece off of 2’’ for that.

Treat newly delivered packages and mail as contagious for 48 hours (Elizabeth)

At the time I posted this, we had very little information on the risks of contamination via packages. I based my recommendation on studies showing other coronaviruses survived for a very long time on other surfaces. Since then someone has released a pre-print on this specific coronavirus on cardboard in particular, which found a half-life of ~2-5 hours. What that means your safety depends on exactly how much your mailman sneezes on it and what the infectious threshold is, which we don’t actually know. However at the concentrations that paper was using, concentration dipped below detection by 48 hours.

Here are the specific recommendations for handling potentially infected packages:

  • Do not touch your face between touching a package and washing your hands or taking off gloves.
  • Spray deliveries with disinfectants.
    • Note that disinfectants are typically less effective on porous material like cardboard. I know of no hard numbers on this.
  • Leave packages exposed to the sun for 1-3 days (this can probably be shortened given the newest information) or a UV lamp for shorter
  • Just don’t touch them for several days.

Benefits

  • Reduces package-to-hand-to-face transmission

Costs

  • Adds time and annoyance to handling packages
  • UV requires a sterilizer
  • Leaving outside may risk theft
  • Letting packages sit takes time and space.
  • Disinfectants are pennies/spray.

Why you might not do this

  • You think surface-to-hand-to-face transmission isn’t important.
  • You’re extremely confident your delivery person is not contagious.
  • You think there is little enough initial contamination pre-delivery that it will have degraded by the time the package reaches you.

Take vitamin D supplements (Connor Flexman)

Vitamin D deficiency has a surprisingly strong link with respiratory infection.

  • Study says 4x rate of respiratory infection in the very deficient, but doesn’t see an obvious effect in the partially deficient, so slightly weird statistics.
  • Study says very large effects in children
  • WHO says vitamin D supplementation may reduce respiratory infections in children
  • Study says no effect from supplementing after already sick, so get on this before infection

While this hasn’t been verified for COVID-19 in particular, it does seem plausible that it applies, and that a supplement can treat it.

Benefits:

  • Reduces respiratory infections, via unclear mechanism.

Costs:

  • 2.5 cents/day using the brand I recommended (recommended to me by a doctor but not otherwise verified), cheaper probably available.

Why you might not do this:

  • You’ve tested your vitamin D recently and levels were normal or high (as a fat soluble vitamin, it is possible to overdose on)
  • You don’t think the results from general respiratory infections transfer to COVID-19 in particular.
  • You think you get enough vitamin D from the sun, and will continue to do so during periods of isolation.
  • You don’t believe supplements can convey health benefits.

Have electrolytes on hand and use once ill (tragedyofthecomments)

COVID-like illnesses frequently cause loss of electrolytes through sweating and diarrhea, which are not replenished from food due to appetite suppression. Insufficient electrolytes can lead to digestive and neurological problems.

The exact form of this is up for debate: some people feel that salt, maybe with sugar, honey, or molasses, is sufficient. Others thought that the magnesium and potassium from a dedicated electrolyte powder/concentrate/drink, or the ease of consumption while sick, was beneficial. Once you’ve gone that road, there are lots of electrolyte supplements with additional vitamins and minerals you might also be missing, leading to something of a paradox of choice for me.

No one disagreed that some form of electrolyte is good to drink to once sick, just what exact form that should take. Choosing any one of these is more important than which one you choose.

Forms you might take, with approximate cost:

Benefits

  • Prevent electrolyte insufficiency, which can lead to neurological and digestive issues

Why you might not do this

  • Personal experience hating electrolytes
  • Inability to distinguish when you’ve had “enough” (since too much is also dangerous)

Maybe: Buy a pulse oximeter (juliawise)

Coronavirus moves from unpleasant to dangerous when your blood oxygen saturation level is too low. A pulse oximeter can tell you when that is happening, providing a clearer line for when to seek medical attention, which is especially important as the risks to contact with the medical system rise. However many people felt that you should ignore a low pulse ox if you felt fine or a high one if you felt short of breath, so it didn’t add anything to the process, an argument I find pretty compelling.

Benefits

  • Certainty in when to seek medical attention, especially if you can’t trust your internal sense of being out of breath (due to e.g. panic attacks).

Costs

  • $30

Why you might not do this

  • You trust your internal sense of being out of breath or not.
  • You expect medical care to be unavailable or net-negative no matter what.

Thank you to Raemon and Ben Pace for comments on this document.

Thank you very much to Julia Wise, Finan Adamson, Connor Flexman and Connor Flexman for this justified practical advice.

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I'd like to suggest not using ibuprofen, or any other anti-inflammatory (NSAID or steroid: also includes aspirin, cortisone, etc. with the presumed exception of pre-prescribed steroids for e.g. asthma).

This is on the basis of this article from the BMJ. In summary, there are a handful of COVID-19 specific cases of young fit people becoming severely ill following ibuprofen use, combined with small studies on SARS-CoV and other illnesses.

Paracetamol should probably be used instead of ibuprofen/NSAIDs.

This seems like a cheap switch as they're likely roughly equivalent in symptom control excepting this effect. Please let me know if you see or read any reason this may be dangerous/untrue. (Is this an appropriate place to post this? Or does it belong in the generalised advice thread?)

paracetamol a.k.a. acetaminophen appears the safest thing to take but if you have a high temperature I would avoid any anti-pyretic medications.

A fever is a good thing - it's making the body inhospitable for viruses when they start invading.

Suppressing this immune response at the early infection "fever stage" potentially allows the virus to get hold.


Ride it out, help your body by curling up in a blanket.

Stay hydrated and let your body's defences work.

I had to look it up: https://en.wikipedia.org/wiki/Antipyretic

So to be clear, you're saying that paracetamol is probably safer than NSAIDs, but avoid even that if you can?

I am trying to keep my wording simple - not managed it here so thanks for asking.

pyrexia = fever.

pyro ~ heat, fire (from both Latin and Greek) pyromaniac a more familiar word?

so anti-pyretic is something "against-fever" i.e. treats a fever/reduces temperature.

I would not take anything to reduce my temperature and I would recommend the same to friends and family, so yes I suggest avoiding paracetamol too.


Personal note - I eat a clove of raw garlic if I think I've picked something up. Giving it a really good crunch between the teeth to release the juices. Not pleasant (even to a garlic lover, and a little easier to take wrapped in bread) but great for keeping people away for a few hours....

Garlic has been shown to have anti-viral properties, no idea if it has any affect on the coronavirus but unless there's a reason not to take it, it's worth a shot. (I wouldn't bother with garlic tablets - just fresh)

Fwiw Chris Masterjohn (see below) also recommends garlic. He recommends crushing it before eating though:

180 micrograms per day of stabilized allicin; or one clove of fresh, raw garlic, crushed, exposed to open air for ten minutes, and eaten without cooking or mixing with other ingredients; or 4 grams of garlic powder, mixed with water, exposed to open air for ten minutes, and eaten without cooking or mixing with other ingredients.

...

Garlic does not contain allicin itself. Rather, it contains alliin, which is converted to allicin within ten minutes when raw garlic is crushed, or when garlic powder is mixed with water, and either are allowed to sit at room temperature in the open air for ten minutes.

Having been in isolation for the last 10 days with a possible covid19 case (gut says no, head says hope so because we're past the worst).

I felt a bit rough yesterday.

Temperature 36.6 C which is normal sublingual (under the tongue) reading for our thermometer.

I crushed some garlic (oh 1st world problems not being able to find the inner bit of the garlic press).

Whilst giving it 10 minutes to brew I decided digital application to the nasal mucosa might be an efficient way to use the juice, targeted application a primary infection site.

(yes - I stuck my finger in the juice and then up my nose. Different finger for each nostril, gotta maintain some standards!)

I did not know this.

Have you any links to more info?

I don't personally know more than that. The citation for the second bit that I quoted is: Lawson, L. D. & Hughes, B. G. Characterization of the formation of allicin and other thiosulfinates from garlic. Planta Med. 58, 345–350 (1992).

WHO doesn't recommend avoiding Ibuprofen for COVID-19 symptoms.

Source: https://twitter.com/WHO

I personally do recommend avoiding NSAIDS (but not other painkillers) for any cold, common or uncommon, and I have an anecdote to base my choices on.

In 2018, I got a cold (no idea whether rhino or corona), and I figured I'd take a single ibuprofen because the inside of my nose felt sore where it was pumping out the mucus. Within a day it turned into a horrible chest cold. Not only was the mucus I coughed and sneezed unpleasantly thicker, so was the mucus I was swallowing, despite my usual cold hydration routine. At night, I had to lie prone (on my belly) and cough for ten to twenty minutes into the trash can to clear my lungs enough to stop coughing and sleep. By the time I fell asleep, I felt like I'd jogged a quarter mile.

Even after all other symptoms faded away after two weeks, I had to continue this nighttime routine. I just wasn't getting better. And then the daytime cough turned into a dry persistent cough. It took me another two weeks of this hell to finally see a doctor. They prescribed a mucus reducer and cough reflex suppressor, both with the potential for serious side effects which I didn't experience. This worked, though my usual back-of-the-throat mucus remained sludge-like for another month.

I will never take an ibuprofen during a cold again. Even if it did something for the pain inside my nose, any pain reduction was overshadowed by the other symptoms, and the possibility that it somehow exacerbated the symptoms would be enough to make me avoid it even if it were the only painkiller available.

For every cold since, I've taken one 50mg zinc pill (with food) as soon as I noticed the characteristic sinus dryness/thirst that heralds the arrival of a cold, and DayQuil/NyQuil generics during the day and night respectively during the symptoms. None of these colds have resulted in more than two days of work missed, and none have become chest colds.

In March, I had a cold I caught at the post office that started with the same nasal pain I remember from 2018, plus slightly thicker mucus and a lack of taste for salt, so I plan to get a COVID-19 antibody test as soon as it's available to see if I accidentally killed the big one with my usual cold routine.

Some notes / proposed additions or clarifications:

  • The #1 hazard noted about copper tape turned out to be cutting yourself on the edge of the tape while applying it (4 independent reports I'm aware of, including myself.) Maybe worth mentioning.
  • The 24-hour figure from the abstract of the paper about virus survival is misleading (all those numbers reflected the time of the last datapoint they saw virus in, notwithstanding the time of the first virus-free datapoint.) Those numbers (and the whole abstract) were all removed in v2 of the paper (https://www.medrxiv.org/content/10.1101/2020.03.09.20033217v2.full.pdf -- you may want to update the link in the post.) So "viable virus could be detected up to 24 hours on cardboard" actually means that it dropped below detectability somewhere in the 24-48h window. The half-life estimation graphs were also made much larger and easier to read in v2; eyeballing the graph, the cardboard number looks to have a median of around 24h, but a distribution that extends outward closer to 36h or 48h. (Although, as you say, this is depending on the concentrations they were using; the half-life, which I believe was reported correctly, is the more important figure.)
  • On vitamin-D, if you haven't seen this, someone found a meta-analysis that sort of suggests a benefit even for people with adequate blood levels, if you squint a little bit. (I believe it was a subgroup analysis that showed this, with the subgroup being "taking it daily/weekly, rather than as a bolus". Which does seem to match how anybody self-supplementing would take it.) https://www.bmj.com/content/356/bmj.i6583

Also, "viable virus could be detected" seems potentially different from "you could get infected from handling it" (in either direction). Your immune system is more robust than the cell culture they use to detect, so many 'detectable levels of virus' are still safe, and the detection method requires diluting the contaminated swab, which means that you coming into contact with the undiluted thing might have nonzero risk even when the test can't detect anything.

But based on my limited understanding of what's going on, the threshold is within a doubling or two of what's sensible; not diluting at all should correspond to the 10^0 line on the graph, which their model suggests should be hit within 20-45 (point estimate: 30) hours of when virus is deposited on the box. So unless you're somehow managing to concentrate the virus, that's the point at which it couldn't infect a cell culture without an immune system.

I'm annoyed at the paper authors because I knew to look for this (due to our earlier conversation) and I checked and the phrasing was just that misleading.

Have fixed.

V2 of that paper also corrects the half-life error in v1 discussed by Vaniver here.

The OP has the incorrect values from the first paper. Annoyingly v2 doesn’t give actual numbers but it looks like ~2.5 - 5 hours to me.

Thanks, I am not best pleased about relying on data from a paper that turns out to have been so sloppy. (I guess a rush was understandable under the circumstances, but I think checking all the calculations twice was also arguably imperative under the circumstances! And the misleading abstract was just dumb.)

I'm glad that they ran this experiment, since this is a core uncertainty, and think we should accept that the price of posting drafts is that you have to read them carefully to spot potential errors; having the graph of the raw data a few days earlier was worth having to eyeball the analysis myself to check their numbers.

Yeah, agreed overall. I would not want to discourage literally our only source of direct data on this from doing it again. But ugh, why can't everyone in the entire world please be like, significantly more careful about everything, all the time? (Preceding sentence is rhetorical and is me making fun of myself for making unreasonable demands.)

Fixed, thank you.

According to this article, it seems clear by now that low oxygen is in fact dangerous even when you feel fine, so buying a pulse oximeter is useful.

https://www.nytimes.com/2020/04/20/opinion/coronavirus-testing-pneumonia.html

Related to treating newly delivered packages as contagious:

Something I've been more worried about than packages are products bought in the store (who knows how long ago that bag of spinach was coughed on?)

If you're doing proper self-quarantining, this won't be something you encounter very often, but it'll still be something to address.

I've been keeping a spray bottle of rubbing alcohol outside of my apartment. Anything I bring inside gets sprayed down before coming in.

Thankfully, most foods come in packaging, so a quick spray down doesn't affect most groceries. Plus, they're easy to rinse off when you get in. It's a bit of a pain spraying each individual item you buy before bringing it inside, but it doesn't actually total more than a few minutes.

It's also good to have the rubbing alcohol outside so that you can spray your hands down before entering your home and touching surfaces. Ideally, anything that comes inside gets at least a mist of rubbing alcohol; this includes my jacket, a quick spray on my jeans and my shirt.

Chris Masterjohn, who was endorsed by Will Eden once I believe, recently sent an email to his list about the coronavirus where he says among other things

For example, I always recommend vitamins A and D during cold and flu season. I see people making the same recommendations for the coronavirus. But after looking at the research, I'm actually restricting vitamins A and D while the coronavirus threat remains high or uncertain.

He's selling a report he put together which has more details here.

Later edit: Masterjohn seems more keen on Vitamin D nowadays https://chrismasterjohnphd.com/covid-19/finally-confirmed-vitamin-d-nearly-abolishes-icu-risk-in-covid-19

Have you read the report and is it worth $10 ?

To be clear, he recommends for getting normal levels of vitamin D and A, but against supplementing. For someone likely to be deficient, I guess that might mean supplementing small amounts, or larger amounts every few days.

I've skimmed it; he sounds very convincing,[1] and he previously turned me on to zinc. I'm not capable of following the science directly. I wonder if it's worth trying to convince him to release it freely (possibly with a lump sum of money), but first I'd want someone more knowledgable than me to evaluate it. When I raised the possibility on the EA coronavirus facebook group, I mostly got the reaction that he seems sketchy (which, yeah, looking at his website he absolutely does); and that nutritionists in general are unreliable even when they seem to have good science. I'm not sure how much weight to assign to those.

Copying from what I wrote on facebook:

So the argument against vitamin D supplementation is that it increases the amount of ACE2 on our cells. ACE2's normal role is in blood pressure and keeping the lungs and heart healthy. (There's a lot more detail on that in the "detailed scientific analysis" section.) But SARS-Cov-2 gets into cells by hijacking ACE2. It has this in common with regular SARS and only one other known human coronavirus (NL63). Specifically the claim seems to be that ACE2 currently docked on cell surfaces would allow viral entry, and ACE2 that's been shed from cell surfaces ("serum ACE2") "is likely to be protective or irrelevant", though that bit doesn't have a citation.

The evidence that vitamin D increases ACE2 seems to be mostly based on rat studies. There were three supporting this, three contracticting (of which one was on humans). But two of the contradicting studies (including the one on humans) looked at serum ACE2 which may not correlate with docked ACE2. The other one had a thing going on with kidney injury that could have caused the effect. He concludes that "On the balance, vitamin D is likely to increase ACE2 expression" and recommends against supplementing it.

(I think the argument against vitamin A supplementation is also that it increases ACE2, but I haven't looked closely at that.)

So I guess concrete(ish) questions that I have:

  • Does SARS-CoV-2 indeed get into cells by taking advantage of ACE2, and specifically ACE2 docked on the cell surface? Wikipedia on ACE2 says "ACE2 receptors have been shown to be the entry point...", and points out that receptors are different from ACE2 itself.
  • Are there experimental/observational studies on the effects of Vitamin D supplementation on SARS?
  • Two of the rat studies showed that "calcitriol, the active metabolite of vitamin D ... synergizes with diabetes to increase ACE2 protein" in different parts of rats. Does that mean they only tested on diabetic rats, and would that make the studies not generalize very well?
  • Does this kind of argument have a history of predicting experimental/observational results? I'm reminded of Scott's recent post on the fat diet, which I think roughly concluded "yah that seems like a solid theoretical argument, but all the empirical evidence seems to contradict it so???"

The citations offered for SARS-CoV-2 getting into cells by ACE2 docked on the cell surface: https://science.sciencemag.org/content/early/2020/03/03/science.abb2762 https://science.sciencemag.org/content/309/5742/1864.long

The second one apparently is free, but behind a login screen.

Also, citations for vitamin D raising ACE2:

  1. Xu, J. et al. Vitamin D alleviates lipopolysaccharide-induced acute lung injury via regulation of the renin-angiotensin system. Mol. Med. Rep. 16, 7432–7438 (2017).
  2. Lin, M. et al. Calcitriol regulates angiotensin-converting enzyme and angiotensin converting-enzyme 2 in diabetic kidney disease. Mol. Biol. Rep. 43, 397–406 (2016).
  3. Cui, C. et al. Vitamin D receptor activation regulates microglia polarization and oxidative stress in spontaneously hypertensive rats and angiotensin II-exposed microglial cells: Role of renin-angiotensin system. Redox Biol 26, 101295 (2019).
  4. Andersen, L. B. et al. Vitamin D depletion aggravates hypertension and target-organ damage. J. Am. Heart Assoc. 4, (2015).
  5. Ali, R. M., Al-Shorbagy, M. Y., Helmy, M. W. & El-Abhar, H. S. Role of Wnt4/β-catenin, Ang II/TGFβ, ACE2, NF-κB, and IL-18 in attenuating renal ischemia/reperfusion-induced injury in rats treated with Vit D and pioglitazone. Eur. J. Pharmacol. 831, 68–76 (2018).
  6. Anguiano, L. et al. Circulating angiotensin-converting enzyme 2 activity in patients with chronic kidney disease without previous history of cardiovascular disease. Nephrol. Dial. Transplant 30, 1176–1185 (2015).

The first three are pro, the others are con.

[1] By which I mean, he sounds like he's done lots of research, weighed it up, and followed where it took him. He includes disclaimers like "as a hedge" and "here are some studies disagreeing, which I think is because..."

And since I had to look it up: the RDA is only 600 IU, assuming no sun exposure. (600 IU = 15μg)

selenium may be more important than zinc:

https://docs.google.com/document/d/1q5IH2hGjjdPi-vcs4zOBlArgFJ9iSDdZVoceevUPI9c/

Note that my only mention of zinc in that comment was relating to zinc lozenges and the common cold. It seems like you're talking about dietary zinc and Covid-19.

I've read it, and I'm guessing it's worth $10. I'm making some adjustments to my supplements based on the advice.

Mask supply via alibaba/aliexpress seems to have ramped. I predict no shortage within a few weeks.

I recall there being some concern that a residue can build up on the copper tape making it less effective. Certainly the tape on the back of my phone is discolored now.

If the tape ended up being not effective but it made people complacent such that they didn't clean the surfaces as much, that could be worse?

Did this get resolved?

I write this atop a mound of copper tape.

Everything I've seen so far seems to suggest that copper oxide is still anti-microbial, but I haven't really attempted to research this, so take that for what it's worth (which is little.) (I've actually become curious whether having it on my hands -- which are visibly turning a bit blue-green where they rub against the copper -- might have further antimicrobial benefits. But this is idle speculation I do not intend to do anything with.)

If you find a link let me know and I'll investigate/probably include it.

The one potential downside of copper is that it may have reduced efficacy when cleaned multiple times using normal cleaning products.

In a study where copper surfaces were inoculated with bacteria in 1% solutions of albumin, dried, and subsequently cleaned with 70% ethanol or 1% sodium hypochlorite, there was a build-up of residues and a concomitant decrease in killing efficiency (1). On the other hand, it was reported that copper surfaces remained active when soiled (42). Also, it was found that there was no reduction in killing efficiency over 30 cycles of bacterial inoculation, followed by cleaning with a 1% nonionic detergent solution (M. Solioz and C. Molteni, unpublished observations).

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3067274/#r1%20is%201%%20nonionic%20detergent%20solution%20(which%20can%20be%20found%20on%20Amazon

https://drive.google.com/file/d/1-nXiUm-WdhapbqngHkM8tXOovuIZuPoW/view?usp=drivesdk

Might want to try metal cleaning products like Brasso or Neverdull, instead--with the caveat that you definitely want gloves and possibly want ventilation while using those.

I'm not sure this has been mentioned so, if you've got a thermometer ...

Get to know your normal temperature.

Take it when you get up, middle of the day and before bed. (clean with alcohol after each use) Nice chance to make a graph.

There's daily fluctuations in temperatures and method of taking it influences the readings so stay consistent. (rectal most accurate method but might be the least popular site - especially if sharing equipment!)

My normal sublingual temperature is 36.6 C

If you know what's normal for you then you'll know if it's increased.

Another electrolyte option: Snake Juice . I've used this while fasting 4+ days several times, and it is a massive improvement over just salt. I make it in partial batches, more concentrated, and then drink plain water until I feel balanced:

khafra twist on snake juice--1tsp baking powder, 1 tsp No-Salt, 1/2tsp Himalayan salt, 20-30oz water. Take a magnesium pill with it, and drink water slowly over the next hour until it feels right.

Himalayan salt is somewhat radioactive.

Don't know if I should advise it, but covid has nudged me into finally buying two overalls (one for the summer and one for cooler weather). Very convenient, I just come inside, take it off and place it under the clothes rack in almost a single motion. And it doesn't have all these additional surfaces that a combination of a coat and trousers or skirt has, which I used to touch without paying attention.

Then it's just a step into the shower and I'm free to come into the living space. I would buy a thicker one for even colder weather, but currently my priorities are a bit different.

The drawback of the light one is it doesn't have sleeves; but it cost ridiculous money and I just throw on a light shirt, and it's very easy to hand-wash. The drawback of the heavy one (jeans) is the fact that it makes me look like some kind of technician on a mission :) so I just think of it as my spacesuit. Maybe people who keep track of fashion will have better luck. It was also significantly more expensive, so I bought it for my birthday.

Buying overalls via internet is a bit tricky, since you have to estimate how your trunk's length fits in it (not that it's hard, you just have to remember not to rely only on your height), but the seller can be a great help.

New to LessWrong, but the mission for this site very much speaks to me :) I wanted to chime in to mention that I did a fair bit of research before buying a pulse oximeter. There are a lot of low-priced options, but in reviewing Reddit posts from medical professionals, they did not seem to be trusted. Some recommended the Masimo MightySat, which I got and would recommend. You can buy it directly from Masimo, but it is also sold on Amazon and by Apple. Masimo provides medical devices to hospitals, and the MightySat is one of the two products that they have made available to consumers. Hope that is helpful!

If a person doesn't have health insurance, then is now the time to sign up for temporary health insurance to avoid getting slammed in case you have to go to the emergency room in the future?

[-][anonymous]30
You’ve tested your vitamin D recently and levels were normal or high (as a fat soluble vitamin, it is possible to overdose on)

As somebody who hasn't tested my vitamin D level and doesn't know how (I assume this isn't something you can easily do with standard household materials?) and is worried about the possibility of overdose if I suddenly start supplementing - how should I calibrate on my "likely current vitamin D level" and what level of supplementation is safe?

FWIW, I started taking Vitamin D without measuring my blood levels after reading https://www.gwern.net/Longevity#vitamin-d . I take 2000 IU/day; the NIH site says the "tolerable upper intake level" is 4,000 IU, so I think I have pretty good margins. https://ods.od.nih.gov/factsheets/VitaminD-HealthProfessional

OOPS! I misread Chris Masterjohn's advice. He recommends NO vitamin D supplements until the coronovirus threat is reduced.

You can get vitamin D from sunlight. You can't overdose this way, but you could get a sunburn, which has its own problems. An app like dminder can help you time your sun exposure.

find others in your area who have similar sun exposure to you, and see if any of them were tested

ask a local doctor about local levels

see the maps/prevalences here:
https://docs.google.com/document/d/1q5IH2hGjjdPi-vcs4zOBlArgFJ9iSDdZVoceevUPI9c

LA Times article mentions the nicotinamide riboside/PARP10 connection from Brenner's paper. Taking NR is probably important and certainly safe.

https://www.latimes.com/california/story/2020-05-01/promises-covid-19-vaccine-therapeutics-cure

Perhaps you could also wind thin-ish non-stranded copper wire around a door handle, as if on a spool. This might easier to obtain for some people (or they already have it at home) and won't have the sharp edged that can cut your hand. If it does not want to stay in place, perhaps also put double-sided adhesive tape under it? Haven't had the opportunity to try this yet, just speculating

Beware, some of the very thin bare-looking copper wire you will find is "magnet wire", which is actually coated in a thin layer of clear insulation.

Good point. You can try measuring it with and ohmmeter from the side, there should be ~ no measurable resistance.

Plan: continue to avoid contact with others as practicable, if sick, treat at home exactly as I would any other flu-like illness (rest, electrolytes, etc), begin using pulse oximeter if sickness progresses to shortness of breath, if number hits 90 or less, put on n95 mask and go to hospital.

Keep the inside of your car infection free. Put methylated spirits, and 10% glycerol in a trigger bottle and spray your hands (do the hand wash routine), your keys, and the door handles before entry from risky environments.