Adele Lopez

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What should we do once infected with COVID-19?

Wei Dai's first link was a doc with medical guidelines written by people with medical expertise (though not (explicitly) for civilians, I would expect legal risk to deter medical professionals from making guidelines for civilian use). That link is now dead, but archived here.

It included the South Korean guidelines:

According to the Korea Biomedical Review, the South Korean COVID-19 Central Clinical Task Force guidelines are as follows:
1.        If patients are young, healthy, and have mild symptoms without underlying conditions, doctors can observe them without antiviral treatment;
2.        If more than 10 days have passed since the onset of the illness and the symptoms are mild, physicians do not have to start an antiviral medication;
3.        However, if patients are old or have underlying conditions with serious symptoms, physicians should consider an antiviral treatment. If they decide to use the antiviral therapy, they should start the administration as soon as possible:
… chloroquine 500mg orally per day.
4.        As chloroquine is not available in Korea, doctors could consider hydroxychloroquine 400mg orally per day (Hydroxychloroquine is an analog of chloroquine used against malaria, autoimmune disorders, etc.  It is widely available as well).
5.        The treatment is suitable for 7 - 10 days, which can be shortened or extended depending on clinical progress.
Notably, the guidelines mention other antivirals as further lines of defense, including anti-HIV drugs.

My current strategy is to follow these guidelines (with hydroxychloroquine + zinc) if medical treatment is unavailable, there's strong evidence that the illness is COVID-19, and serious COVID-19 symptoms are present. I'll also have activated charcoal on hand to help mitigate accidental overdoses. I'm trying my best to familiarize myself with the risks involved so that I can make good decisions if the situation calls for it. Of course, my primary strategy is prevention in the first place.

What should we do once infected with COVID-19?

BTW, the google doc appears to have been taken down due to a TOS violation.

What should we do once infected with COVID-19?

You can buy hydroxychloroquine here still (as of March 20th): https://fixhiv.com/shop/coronavirus-drugs/hcqs-400-hydroxychloroquine-400-mg/ which imports it from India. This site also lets you easily buy a prescription for it, FWIW.

Check for G6PD deficiency before taking chloroquine (can be done through the 23-and-me interface) as it can cause haemolysis. Apparently not an issue with hydroxychloroquine: https://www.ncbi.nlm.nih.gov/pubmed/28556555

What should we do once infected with COVID-19?

Just because something is dangerous in overdose doesn't mean that medical supervision is needed: for example acetaminophen, or even water. The relevant thing is that the therapeutic dose is close to the lethal dose for chloroquine, and chloroquine dosing is complicated.

Hydroxychloroquine is 40% less toxic while still being effective, according to this article: https://www.nature.com/articles/s41421-020-0156-0

Medical supervision may not be available if current trends continue, so we must carefully weigh the options available to us.

Does the 14-month vaccine safety test make sense for COVID-19?

From what I can tell, it looks like the main danger is with a live vaccine, where the vaccine can give the disease to a large number of people (biggest actual disaster seems to have been the Cutter incident, which infected 40,000 people with polio).

I assume that the trial is also there to catch potential black swan issues.

IIRC the Covid-19 vaccines on trial are not live, so the case for doing the 14 month watch was not as strong as I expected. Certainly worth considering more carefully at least.

Category Theory Without The Baggage

This is more mathematically justified than you seem to think. Posets are topological spaces and categories, and every space is weak homotopy equivalent to a poset space, which explains why the intuition works so well.

Category Theory Without The Baggage
the traditional presentation of category theory is perfectly adapted to its original purpose

I think this is too generous. The traditional way of conceptualizing a given math subject is usually just a minor modification of the original conceptualization. There's a good reason for this, which is that updating the already known conceptualization across a community is a really hard coordination problem -- but this also means that the presentation of subjects has very little optimization pressure towards being more usable.

What are the merits of signing up for cryonics with Alcor vs. with the Cryonics Institute?

I'm planning to go with ACS, which is a lesser known cryonics organization that has been around longer than Alcor and CI. The price for a full suspension is $155,000 which is in between the CI and Alcor prices.

They don't actually run their own facilities, instead they contract with other organizations, currently CI to hold the vitrified bodies. For doing suspensions, they seem to have their own procedure, and you can additionally choose to have them contract other organizations such as Suspended Animation Inc. (which is the one Alcor uses).

Since they contract, they have increased flexibility which seems quite valuable. In particular, it helps against organizational incompetence which both Alcor and CI seem to have their fair share of. It's harder to find info about the competence of ACS themselves, but the fact that they've been around a long time bodes slightly well.

They also sponsor cryonics research, which is really cool.

Anyway, I'd really appreciate having more people analyze them as a cryonics option before I commit to them!

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