I don't think the experiment design is that weird. This is not the first iDSB system, and the TAM dose was 1.9mg/kg of bodyweight, 2 OOM less than other IDSB papers, administered orally as opposed to intraperitoneally.
And you don't see zero mutagenesis, which I agree would be weird, you see a slight increase in mutagenesis specifically at I-Ppol cut sites, (which are, with a single exception non-coding). I'd have to look at accelerated aging via mutagenesis papers to see exactly how much lower the mutation increase here is vs standard, but I'd expect the rate in this paper to be a lot lower.
Could you be specific about what things, exactly, these results contradict?
I have generally been uncompelled by theories of aging which focus on accumulation of error at the cellular level, NAD+ decline, mutation accumulation, free radical production, etc. The core problem of biological systems is: stochastic inputs, deterministic outputs. Biological systems have a wide variety of mechanisms for error correction and returning to equilibrium. For such theories to make sense, let alone serve as the basis of radical human lifespan extension, you end up asking some rather difficult questions - about information specification and decay in biological systems, about reciprocal causation, the ways that complex systems fail.
These are, as it happens, exactly the questions... (read 2999 more words →)
I feel as though the existence of "Mucky fat" is a relevant datapoint here
https://www.theguardian.com/lifeandstyle/wordofmouth/2012/feb/22/mucky-fat-butties-sense-place
Though it perhaps says something that this seems to have gotten less popular as food has gotten cheaper