It seems largely true to me that it is not hard to create a temporary change in one of the axes, but I am curious if these can lead to permanently changed settings in the long run. I would be very curious to hear from anyone who's created lasting change through an experiment like this and what axis in particular they changed.

Personally, I've experimented with acting much more extroverted than I typically am in certain social contexts (interviews are a good example) and the new setting feels comfortable or even better at times. Gaining more experiences like this certainly makes the new setting seem more appealing but it does not seem to become easier, and I will always revert back to my default setting once the context changes. Maybe the shyness axis is particularly difficult to change.