Chumpai1986
3
Chumpai1986 has not written any posts yet.
Chumpai1986 has not written any posts yet.
I just wanted to add another response here, after thinking about it for a few days. I've read a papers where killed HIV vaccines etc seem promising. So, I think this is a viable strategy, but there are a few issues. As I wrote in my other comment, you are probably mainly stimulating an antibody response, but not a cellular response.
The issue with using UV, it probably a higher chance of viral re-activation. You would probably use gamma irradiation, maybe with heat and chemical treatment also. The issue with inaction is that you potentially alter the antigens.
The other issue is that RNA viruses mutate quite fast. So, you may get... (read more)
So you can generate a killed virus vaccine with heat or chemicals as well.
This method just doesn't generate a very strong immune response compared to live attenuated vaccines. You need an adjuvant. I am guessing having some cells infected by a live virus contributes to a full immune response (induce CD8 T cells etc).
P.S. in the literature, it does seem (at first glance) that killed vaccines require more doses compared to live vaccines.