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Thank you for this post! One feedback - I found this post much harder to navigate than your other posts (and eventually resorted to summary+bookmark); it is much easier for me to parse/navigate when post sections follow your own line of thinking than when they are structured as replies to sections of other peoples' posts.

i have worn this on an airplane with a surgical mask over the exhale valve

Without knowledge of potential interactions, melatonin might be another option - I don't take bupropion, but suspect that one would take daily dose in morning to minimize chance of this side effect as well

Depending on when you got your second mRNA dose, the Israeli data suggests there is significant vaccine decline in vaccine efficacy after 3 months (see ) This does not of course indicate whether a third dose would restore efficacy (presumably by reigniting the immune response in some way) - I suspect it would, however. No need for prize money if relevant - just resharing a link that was already in Forbes

Thanks for this as always! Any thoughts on the variant effectiveness estimates in this paper?

The initial pfizer efficacy study and followups in Israel specifically come to mind.

Potential metrics which may be helpful to consider (from a previous location search for me to live): Minimum sunlight per month, months under 200 hrs of sunlight, days above 90F, days below 32F, snow/rain days per year, violent crime level, property crime level, number of internet providers, average speed test result of internet providers, top advertised speed of internet providers, quality of healthcare, attends religious services at least once per week, rate of cigarette use, rate of alcohol use, rate of binge drinking.

Some of these are direct metrics on experience (ie number of days where climate makes being outside less pleasant), others towards the end of the list are more proxy metrics of concrete data that may give some indication of general level of religiosity/stress/need for escape in the local environment.

Would love any context here - not sure if I should parse the linkpost as random person on internet saying things or if any background that would give me a higher prior that their models are accurate and/or useful.

Fluvoxamine is a prescription drug in the FDA, so your doctor can prescribe it; might work as well. Antiviral procurement is similar if the antiviral you're seeking is a US prescription drug (in any case I'd consider Googling the antiviral name.)

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