This is an awesome self-experiment. Sadly the 100ug dose used might be too low by at least an order of magnitude. How was it chosen?
We've been doing extensive placebo-controlled preclinical mouse trials with orexins and stabilized orexins in the last 6 months. Typically, we use 1 - 1000 ug per mouse per dose. We've found that 100ug intranasally is our common effective dose in mice, to achieve measurable behavioral effects such as improved wakefulness or increased locomotion.
Happy to share more preclinical research data here privately.
Hi! It's time to convert my lurking into an active account. I'm interested in all things related to making the long-term future go well, and I currently run Future Forum.
This is an awesome self-experiment. Sadly the 100ug dose used might be too low by at least an order of magnitude. How was it chosen?
- We've been doing extensive placebo-controlled preclinical mouse trials with orexins and stabilized orexins in the last 6 months. Typically, we use 1 - 1000 ug per mouse per dose. We've found that 100ug intranasally is our common effective dose in mice, to achieve measurable behavioral effects such as improved wakefulness or increased locomotion.
- Happy to share more preclinical research data here privately.
- Scaling drug dosing
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