grrl_nrg

Don’t forget to account for the storage cost of ~$1,000/yr

We don’t actually know that JK He accomplished what he said he did.  He may have tried.  But the results have not been independently verified.  That would require genotyping the parents and children.  So, premature to say that germline editing appears safe in humans.

Thanks for the response.

I thought the following article does a good job of outlining some of the limitations of PRS for embryo selection:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9527452/

Like any new (medical) technology, I think that it's important to consider the ethical implications.  This doesn't mean that we shouldn't do it or allow it, but just that we should be thoughtful about it.

As for clinic success rates, I didn't mean to imply that "they don't mean anything".  It's just that prospective patients should be aware that they can't alwa... (read more)

Great post.  Thank you.  Fertility doctor here and a supporter of ART (assisted reproductive technologies) in general.  A few thoughts (although you touched on a few of these below, worth emphasizing in my opinion):

• PGT-P has not been validated yet, which may take decades to do, if ever.
• The science in terms of GWAS isn't quite there yet IMHO - we don't know all the genes that are important for most traits and we may be inadvertently selecting against some desirable traits, for example.
• Comparing clinic success rates using CDC data is imperfect