I have yet to familiarize myself more with effective altruism to know the details of their metrics, but it seems like the reliance on 'number of lives saved per unit money' doesn't necessarily align with the goal of helping people, which i think this post demonstrates well. And then there's the arguably relevant issue of over-population. If everyone contributed some of their education funding on saving lives, wouldn't the Earth get over-populated before sufficient technological progress was made to e.g inhabit another planet?

Whether or not the first cause argument should be a concern in science, i think Bertrand Russell summarizes its problems quite well:

"Perhaps the simplest and easiest to understand is the argument of the First Cause. It is maintained that everything we see in this world has a cause, and as you go back in the chain of causes further and further you must come to a First Cause, and to that First Cause you give the name of God. That argument, I suppose, does not carry very much weight nowadays, because, in the first place, cause is not quite what it used to be. The philosophers and the men of science have got going on cause, and it has not anything like the vitality that it used to have; but apart from that, you can see that the argument that there must be a First Cause is one that cannot have any validity. I may say that when I was a young man, and was debating these questions very seriously in my mind, I for a long time accepted the argument of the First Cause, until one day, at the age of eighteen, I read John Stuart Mill's Autobiography, and I there found this sentence: "My father taught me that the question, Who made me? cannot be answered, since it immediately suggests the further question, Who made God?" That very simple sentence showed me, as I still think, the fallacy in the argument of the First Cause. If everything must have a cause, then God must have a cause. If there can be anything without a cause, it may just as well be the world as God, so that there cannot be any validity in that argument. It is exactly of the same nature as the Hindu's view, that the world rested upon an elephant, and the elephant rested upon a tortoise; and when they said, "How about the tortoise?" the Indian said, "Suppose we change the subject." The argument is really no better than that. There is no reason why the world could not have come into being without a cause; nor, on the other hand, is there any reason why it should not have always existed. There is no reason to suppose that the world had a beginning at all. The idea that things must have a beginning is really due to the poverty of our imagination. Therefore, perhaps, I need not waste any more time upon the argument about the First Cause." http://www.positiveatheism.org/hist/russell0.htm

A perhaps equally juvenile concern of mine, is whether Wittgenstein himself failed to stand on the shoulders of giants (at least in the Tractatus), by essentially starting from scratch with his own propositions, drawing logical conclusions from them rather than using or at least referring to previous work.