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CRISPR opens up new genetic engineering potential

4y
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Brain-Brain communication

6y
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22

Genetically Engineered Intelligence

7y
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Print ready version of The Sequences

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Recent Comments

Ah, I should have guessed that 'Immersion Learning' had been co-opted a few times before. My above use is my own coinage. By it I just mean jumping in and being exposed to everything you can and letting your brain sort it out, rather than methodically building a cathedral of understanding, one block...(read more)

This is how I prefer to learn as well. I call it "Immersion Learning".

For example, during my first year of Algebra, I carried a Calculus textbook with me to class, and read whenever I was bored. I read through the whole textbook that semester, and understood maybe 20%. I didn't bother doing any pr...(read more)

I do this as well, but I don't "lie" (from the perspective of my core values).

I empathetically accept the other person's ethics and decisions. I allow that common connection to genuinely color my tone and physical expressions, which seems to build rapport just as well as actually verbalizing agree...(read more)

Awesome, thanks for the detailed response. After reading about CRISPR's natural role in bacteria I was curious if it would have targeting limitations. It sounds like it does (needs GGG triplet), but that in practice this isn't a big deal.

You still need to get this system into a cell -- that's an i...(read more)

I'm very curious how many genes can be targeted usefully. One paper succeeded in targeting 5 simultaneously in a mouse model. Given the purported accuracy that is already game changing, but if we can do 100 or 200 then maybe we can do more than merely eliminate some simple single gene disorders.

> Scary enough for ya?

Sufficiently scary, yes.

> That is equivalent to saying you can't understand how mathematics could be a construct; or how mathematical anti-realism could possibly be true.

I assign a respectable probability to anti-realism, and hold no disrespect for anyone who is an anti-r...(read more)

I had a similar experience the first time I supplemented magnesium. Long lasting, non-jittery energy spike. I felt stronger (and empirically could in fact lift more weight), felt better, and was extremely happy. The effect decreased the next few times. After 4 doses (of 50% RDA, spread out over 2 we...(read more)

> If you wipe out the chemical gradient information then how do you know what sorts of ways that the dendrites should regrow in the weeks and months post-resuscitation?

If I wake up and I feel like myself on a second to second basis, I will not be upset if my path through mind space is drastically...(read more)

> if a problem doesn't appear quickly, then it probably isn't that important...

I agree completely, especially about how close we probably are to a successful Biosphere, but just to throw out an example where this is wrong: vitamin B-12 deficiency usually takes a decade to demonstrate symptoms, and...(read more)

> It is dangerous in the same way as bringing John Q. Snodgrass to trial for murder. We might overweight evidence in favor of the hypothesis.

Human intuition is a valuable heuristic. As a mathematician I constantly entertain hypotheses I don't believe to be true, for the simple reason that my intui...(read more)