jsteinhardt

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AI x-risk reduction: why I chose academia over industry

This doesn't seem so relevant to capybaralet's case, given that he was choosing whether to accept an academic offer that was already extended to him.

Covid 2/18: Vaccines Still Work

I think if you account for undertesting, then I'd guess 30% or more of the UK was infected during the previous peak, which should reduce R by more than 30% (the people most likely to be infected are also most likely to spread further), and that is already enough to explain the drop.

Making Vaccine

I wasn't sure what you meant by more dakka, but do you mean just increasing the dose? I don't see why that would necessarily work--e.g. if the peptide just isn't effective.

I'm confused because we seem to be getting pretty different numbers. I asked another bio friend (who is into DIY stuff) and they also seemed pretty skeptical, and Sarah Constantin seems to be as well: https://twitter.com/s_r_constantin/status/1357652836079837189.

Not disbelieving your account, just noting that we seem to be getting pretty different outputs from the expert-checking process and it seems to be more than just small-sample noise. I'm also confused because I generally trust stuff from George Church's group, although I'm still near the 10% probability I gave above.

I am certainly curious to see whether this does develop measurable antibodies :).

Making Vaccine

Have you run this by a trusted bio expert? When I did this test (picking a bio person who I know personally, who I think of as open-minded and fairly smart), they thought that this vaccine is pretty unlikely to be effective and that the risks in this article may be understated (e.g. food grade is lower-quality than lab grade, and it's not obvious that inhaling food is completely safe). I don't know enough biology to evaluate their argument, beyond my respect for them.

I'd be curious if the author, or others who are considering trying this, have applied this test.

My (fairly uninformed) estimates would be:
 - 10% chance that the vaccine works in the abstract
 - 4% chance that it works for a given LW user
 - 3% chance that a given LW user has an adverse reaction
  -12% chance at least 1 LW user has an adverse reaction

Of course, from a selfish perspective, I am happy for others to try this. In the 10% of cases where it works I will be glad to have that information. I'm more worried that some might substantially overestimate the benefit and underestimate the risks, however.

Making Vaccine

I don't think I was debating the norms, but clarifying how they apply in this case. Most of my comment was a reaction to the "pretty important" and "timeless life lessons", which would apply to Raemon's comment whether or not he was a moderator.

Making Vaccine

Often, e.g. Stanford profs claiming that COVID is less deadly than the flu for a recent and related example.

Making Vaccine

Hmm, important as in "important to discuss", or "important to hear about"?

My best guess based on talking to a smart open-minded biologist is that this vaccine probably doesn't work, and that the author understates the risks involved. I'm interpreting the decision to frontpage as saying that you think I'm wrong with reasonably high confidence, but I'm not sure if I should interpret it that way.

Covid 12/24: We’re F***ed, It’s Over

That seems irrelevant to my claim that Zvi's favored policy is worse than the status quo.

Covid 12/24: We’re F***ed, It’s Over

This isn't based on personal anecdote, sudies that try to estimate this come up with 3x. See eg the MicroCovid page: https://www.microcovid.org/paper/6-person-risk

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