My response from a few days ago: https://x.com/Meta_Celsus/status/1973152477681012893

Basically this approach is scientifically interesting, but not going to work for healthy babies anytime soon because of massive problems with chromosome segregation and imprinting.

Agreed. Even if this tech gets working, it will be very hard to catch up to photovoltaics.

Yeah, if anyone is interested in learning more, this is called the phasing problem. For common enough variants, it's often possible to figure this out by looking at general patterns of co-inheritance if you have a large reference dataset for the population (see: https://www.nature.com/articles/s41588-023-01415-w). Long read sequencing which you mentioned is another approach. But you're right that these days it would just be cheapest to get the parental genomes (assuming that's an option).

Thank you!

I really liked the concert at LessOnline (especially "The Ninth Night of November" which is rather personal for me because FTX told me on November 3 2022 that they would fund me, and November 10 that they were in trouble, and November 14 that "the funds to support your work are gone with everything else".

So, this is just a reminder to please release the album (unless you already did and I just can't find it).

Specifically the CITES regulation makes it difficult to get nonhuman primate cell lines from researchers outside of the USA, or share our cell lines with them. There's not any good conservation reason for this.

Thanks for your support! I really think you're making a great impact here.

I'm sorry to break this to you, but cloning requires live cells, not just DNA. This is one of the reasons why it's so hard to bring back the woolly mammoth. (The other reason is that it's really hard to do IVF on elephants.)

So if you want to make a clone, you'll need to do something like what I did (take cells and preserve them in liquid nitrogen).

Preserving the entire brain is much more difficult than preserving cells, and requires specialized equipment.

I don't know if targeted crossover is plausibly feasible.

It is definitely feasible. This is how artificial gene drives work.