michaltill

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Most sources that I read often refer to this overfeeding trial of extra 1000 kcal of saturated (SAT), unsaturated (UNSAT) or carbohydrates (CARBS). Not that many people involved (38), but a good thing is that it is a controlled randomized trial where participants were given the food. Endpoints measured are liver fat content change via two pathways. So not an serious event like CVD or stroke, but a marker (fatty liver) that is easier to measure and an endpoint that we know that is really bad for health. Results: overfeeding with SAT is most harmful, more than CARBS and more than UNSAT.  Another piece in the puzzle (in different setting and with different outcome) that SAT is probably bad.

Saturated Fat Is More Metabolically Harmful for the Human Liver Than Unsaturated Fat or Simple Sugars
https://diabetesjournals.org/care/article/41/8/1732/36380/Saturated-Fat-Is-More-Metabolically-Harmful-for