mpoon

Many of the most devastating human diseases are heritable. Whether an individual develops schizophrenia, obesity, diabetes, or autism depends more on their genes (and epi-genome) than it does on any other factor. However, current genetic models do not explain all of this heritability. Twin studies show that schizophrenia, for example, is 80% heritable (over a broad cohort of Americans), but our best genetic model only explains ~9% of variance in cases. To be fair, we selected a dramatic example here (models for other diseases perform far better). Still, the gap between heritability and prediction stands in the way of personalized genetic medicine.

We are launching Tabula Bio to close this gap. We have... (read 438 more words →)

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LESSWRONG
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mpoon

mpoon

mpoon

Tabula Bio: towards a future free of disease (& looking for collaborators)

mpoon

mpoon

mpoon

Tabula Bio: towards a future free of disease (& looking for collaborators)