Olli Savolainen
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Olli Savolainen has not written any posts yet.
Olli Savolainen has not written any posts yet.
... (read more)So this is why if you read the CNV studies and you look at the hits they identify, and how many subjects are covered by the identified hits, you find that like, maybe 2% of the cohort will have one of those specific identified hits and lose 2 IQ points or gain 2 kg of fat etc. So you can see how that would work out in embryo selection: you'd be able to avoid that loss, which is meaningful! ...in a tiny fraction of all embryos. On average, you'd just sequence them all, find no known pathogenic variant, and shrug, and use the SNP PGS like usual, having gained nothing.
Also, of course,
I would advice you and others to be more blunt when advancing your case.
No one – not even you – remembers if we were good or bad, why we fought and why we died...No! All that matters is that two stood against many, that is what's important.
There are objective measures for fitness and quality of individuals, too. But it would be insulting and also kind of weak and evasive to refer to your superior figures of merit in your personal business and contentions. If it is about your personal survival or physical safety, appealing to your goodness, your usefulness, is pretty much the definition of slavishness. (I have never read Nietzsche, just... (read more)
I am glad to see oat foods taking new forms and gaining popularity with new audiences. I welcome all enthusiasts sharing what they have learned.
But you have to acknowledge the existing traditions and their expertise. It would be a tragedy, if, instead of seeds of civilization, you were spreading some meaningless imitations that have no roots. Your post has many layers of sophistication, but I believe you have omitted the true kernel of the matter.
I don't know what guava tastes like, but I strongly suspect it does not belong in an authentic oatmeal porridge. The canonical additions are apple or apple jam with cinnamon, or blueberry. It is ok to experiment (e.g.... (read more)
The other major question I'm grappling with is why there is an obesity-elevation gradient.
A guy is going alone through the wilderness, with a solar powered icebox on his back. He crosses a raging river by swimming. He slashes his way through a jungle. He is blasted by sun on an endless desert. It's been weeks and he has no company at all, save the bleached bones (and ice boxes) of those who did not make it. He climbs a mountain until he finally comes to a cave in the snow. Inside is a man with beard like silvery horsehair, eyes like fire. Very old but fit as a mountain goat.
"O wise sensei,... (read more)
Of course if one insists on some of the assumptions you did not need, namely doing the standard microcanonical ensemble approach, it trivializes everything and no second law comes out.
In microcanonical ensemble the system is isolated, meaning its energy is fixed. Microstates are partitioned into a macrostates by their energy (stronger version of your assumption of macro being a function of micro), so they don't switch into a different macrostate. If you take them to be energy eigenstates, the microstates don't evolve either.
I don't endorse the idea of a macrostate secretly being in a certain microstate. They are different things, preparing a microstate takes a lot more effort.
When this phrase is used it is maybe implied that the equilibriating happens much faster and further than the actor (usually a democratic regulating body) expected, and that they are too slow to "evaluate medium term, make corrections".
One other potential benefit of an unstable mechanism is that there is no energy loss that comes with damping, in other words the many possible errors are not rejected as heat. Instead, the error can be measured with a much smaller energy cost, and then a reversible correction can be made that on average costs no energy. In concrete terms this can be pictured as replacing a dashpot or a shock absorber with a finely controlled quick response linear electric motor (one that can reproduce and correct any error that occurs). Of course a dashpot-like solution is usually simpler and more reliable. I have come to appreciate reliability even more as I've grown older.
Controlled experiments and a connected body of theory. The set-up of experiments needs to be freely adjustable to check that most particularities and circumstances of the experiment can indeed be ignored and what remains has qualities of a "natural law".
This is a strong definition, it somewhat excludes cosmology and a good deal of biology.
Xylitol seems to be a source of oxalic acid. I don't know if it metabolized into that form by the body or gut microbiome, or both, but it definitely shows up in urine. It says "Excessive use may cause laxative effects" on the bag of chewing gum, but I think oxalic acid is a much bigger concern with potential for long term damage to kidneys and joints. Highly processed vegetable rich diets might already contain excessive amounts, especially for people with gut problems and fat malabsorption.
If were talking about easy adjustments to fight caries, how about switching to porridge based breakfast (in place of cereals or muesli) and opting for 100% oat bread instead of dry white bread. This in my experience has a big effect on how much and for how long starchy matter adheres to fissures in teeth.
(I feel like I'm betraying Finland by attacking xylitol. I'm making up for that by talking up oats and porridge.)
Thank you for the information. Now I feel a lot safer when eating osso buco.
But why is it a ruminant species having these problems again? Why not chickens or whales or fish? Perhaps it's the grazing lifestyle combined with unnaturally high population densities and immobility. Or herbivores having low natural resistance to prion pathologies.
I believe the ultimate origin of bovine pathogenic prions is in high temperature processing of skins, offal, and especially CNS tissue and bones (prion is expressed in the marrow more than average). Remember, we used to feed bonemeal and other residues of bovine origins to cows until the mad cow episode. Some of that matter had gone through stages... (read more)
I agree that woo is bad. And microbiome is of course irrelevant wrt boosting IQ. But a good part of the post was about improving health, and microbes do have serious downsides on that front. If you don't have the good ones you are at a much greater risk of being colonized by the bad ones. And disease still has a non-zero negative effect on people's brain development and cognition.
Removing bad behaviour from microbiome would be quite a bit more effective and easier than fixing genes, for fighting disease. And many of the diseases with a significant genomic risk scores mentioned in the post probably have an unknown necessary pathogenic cause.
Here's a paper (Cochran&Ewald) with simple powerful arguments, I always try to push it to any doctors I meet.