Specifically the folinic acid hypothesis is that this is an atypical autoimmune-instigated form of CFD, not the genetic type which typically manifests very rapidly. Look up Folate Receptor Alpha Autoantibodies. My strongest claim is that something environmental may be causing an uptick in autism, even accounting for its strong heritability; with a subset of that claim being "maybe vaccines". I don't believe this strongly enough to write more than a shortform pondering it.
The putative method by which leucovorin (folinic acid) might be a cure for some subtype of autism is that folate receptor autoantibodies (FRAAs) block normal sources of folate reaching the brain, causing a form of Cerebral Folate Deficiency (CFD). It's claimed that folinic acid is an atypical source of folate which can still reach the brain in someone with those antibodies. On this theory, that subtype of autism is an autoimmune disease.
No conclusive evidence links vaccinations to autoimmune diseases, but conditional on folinic acid working, we should maybe look more closely at what would cause the autoimmune disorder, and update positively on some version of the vaccine theory?
I have been experiencing something similar recently on semaglutide, although my hypothesis was simply calorie deficit homeostasis. I’d previously dieted and lost 18 lbs without, and the main difference was the willpower required to do it, the fatigue and associated anhedonia was the same. This might be different if you’re not at all tired?
Would “explain this concept to a younger child” be a better classroom assignment?
What was the point about the carpet rods? You seemed like you were going somewhere interesting with that!
FYI, Mox will also be open to LessOnline ticketholders in the week between LessOnline and Manifest. This is more for people who are flying in a few days early and just need a place to get work done, for socializing highly recommend buying a ticket to Arbor summer camp!
FYI, Mox will also be open to LessOnline ticketholders in the week between LessOnline and Manifest. This is more for people who've got a flight out a few days late and just need a place to get work done, for socializing highly recommend buying a ticket to Arbor summer camp!
The code to enter is 1112# ! If you're new to the space, come up to the 4th floor and I, Mattie, or Austin will help you get oriented :)
The idea of kill markets are of course not so new. One prominent example was the practice of paying bounties for Indian scalps which was practiced by various US government and white civilian entities during frontier conflicts against natives. They were not the first to adopt this practice but they were the ones to spread it across the continent. This incentivized wholesale extermination of native nations, and predation on innocents, rather than mere military submission, a common outcome of those frontier wars.
I think that this is a minor point, yes, not the main point. It’s a subtlety that many miss, not the key reading.
But likewise, I’ve found a prod in Omelas that goads me personally more than the main theme does. It’s the unspoken “and if you’re that unsatisfied with that perfect city, with one single justifiedly suffering child, what in god’s name are you doing about this world, with so much less good, and so much more suffering, so much less justified?”