Rossin

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What to make of Aubrey de Grey's prediction?

So to clarify, I think there is merit in his approach of trying to engineer solutions to age related pathology. However, I do not think it will work for all aspects of aging right now. Aubrey believes that all the damage caused by aging are problems that we can begin solving right now. I would suspect that some are hard problems that will require a better understanding of the biological mechanisms involved before we can treat them.

So my position is that aging, like many fields, should be investigated both at the basic biology level and the from the perspective of trying to design therapeutics, because you don’t know if you can fix problems with current knowledge unless you try. However, if you fail to adequately treat the condition you want basic research to be ongoing.

What to make of Aubrey de Grey's prediction?
Answer by RossinFeb 28, 202019

As someone who works in biological science, I give the claim very little credence. I am someone who is very interested in Aubrey's anti-aging ideas and when I bring up aging with colleagues, it is considered to be a problem that will not be solved for a long time. Public opinion usually takes 3 to 5 years to catch up to scientific consensus, and there is no kind of scientific consensus about this. That said, the idea of not having to get old does excite people a lot more than many other scientific discoveries so it might percolate into mainstream much faster than other ideas. Still my sense is that the overwhelming majority of scientists are not on board, which will make it very unlikely for this shift in public perception to happen.

Further, I do not know why he would expect the public to care this much about the issue that it would be impossible to be elected without it. It's not like there's huge electoral pressure to increase spending on cancer or heart disease research, which are diseases that essentially everyone is impacted by (directly or indirectly). The idea that there will be huge pressure for aging research seems absurdly over-optimistic.

So I would give this claim very little credence personally despite the fact that I do think we can at least make major strides into treating age-related pathology within the coming decades if it receives sufficient funding.

Book Review: The Secret Of Our Success

I think a very interesting aspect of this idea is that it explains why it can be so hard to come up with truly original ideas, while it is much easier to copy or slightly tweak the ideas of other people. Slight tweaks were probably less likely to get you killed, whereas doing something completely novel could be very dangerous. And while it might have a huge payoff, everyone else in the group could then copy you (due to imitation being our greatest strength as a species) so the original idea creator would not have gained much of a comparative advantage in most cases.

What is your personal experience with "having a meaningful life"?

I think a number of the example answers are mystifying meaning. In my view, meaning is simply the answer to the question "why is life worth living?". It is thus a very personal thing, what is meaningful for one mind may be utterly meaningless to another.

Yet as we are all humans, some significant overlap in the sorts of things that provide a sense of reason or gladness to being alive exists.

I will quote my favorite song, "The Riddle" by Five for Fighting, which gives two answers: "there's a reason for the world, you and I" and "there's a reason for the world, who am I?"

I think these capture the two most common sources of meaning for people. Our interactions, love and care for others is one major aspect of what, for many, makes life worth living. And the other is looking inside oneself, finding the things you cherish for their own sake and the moments of flow and joy you are able to find in the world.

Laughing Away the Little Miseries

This was very interesting. There seems to be a trade off for these people between their increased happiness and the ability to analyze their mistakes and improve, so I am not sure I find it entirely attractive. I think there is balance there, with some of the people studied being too happy to be maximally effective (assuming they have goals more important to them than their own happiness)

Stoicism: Cautionary Advice

I think these are very important points. I have noticed some issues with having the right responses for social situations (especially laughing when it's not entirely appropriate), which is something I've been working on remedying by paying closer attention to when people expect a serious reaction.

The issue of ignoring problems also seems like something to look out for. Just because something does not make you feel bad should not mean you fail to learn from it. I think there is a fine balance between learning from mistakes and dwelling on them, which is another, related skill.

Losing risk aversion and motivation seem unlikely to be problems for me personally, as what you're calling the stoic mindset seems to push those towards a more ideal spot from my natural inclinations. However, I suspect this advice may be critical for others, though they would never have occurred to me as associated problems. This is why I always feel hesitant to give self-help advice.

Inadequacy and Modesty

I think the example with the lightbulbs and SAD is very important because it illustrates well that in areas that humanity is not prioritizing especially, one is much more justified in expecting civilizational inadequacy.

I think a large portion of the judgment of whether one should expect that inadequacy should be a function of how much work and money is being spent on a particular subject.

Great sequence, I've really enjoyed it.

And I definitely agree with this view of rationality, I think the idea of incremental successes enphasizes the need to track successes and failures over time so that you can see where you did well and where you did poorly and plan to make the coin come up heads more often in the future.

The Balance Between Hard Work and Exhaustion

You don't build strength while you're lifting weight. You build strength while you're resting.

I think this phrase is particularly helpful as something to repeat to yourself when feeling the impulse to push through exhaustion when you know that you really ought to rest. I'll almost certainly be using it for that purpose when I'm feeling tempted to forget what I've learned.

The Balance Between Hard Work and Exhaustion

Yeah, I think the biggest problem for me was that I felt deficient for failing to live up to the standard I set for myself. I sort of shunted those emotions aside and I really fell out of a lot of habits of self-improvement and hard work for a time. So I would say the emotional fallout lead to the most damaging part (of losing good habits in the aftermath).
Thinking about tradeoffs in terms of tasks completed is a good idea as well, I'll try doing that more explicitly.

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