Humanity continues as it has for the last several thousand years, learning new things, changing its views, constantly refining its thoughts and actions. It makes mistakes and learns from them, or fails to learn and repeats them, repeatedly. It's splintered into many groups who hate each other for no particular reason, create wars, famine, and disease, despite wealth and cures. There is a great disparity in all things between different people in different places, including knowledge, wealth, and enjoyment of life.
Evolution turns out to hold sway even once humanity tries taking over the process, and countless lines of human and technological enhancement become 'extinct' while others flourish to take their place. Utopia, dystopia, and weirdtopia exist together in varying degrees and in different locations among humanity's diaspora, forming a highly complex, dynamic, adaptive universe that continues on despite all the great changes.