Do the rates of full-term and adult survival rates in iPSC mice match that which could be achieved by normal IVF, or do they indicate that there is still some suboptimality in culturing of tetraploid aggregated iPSC embryos? I'm not familiar with the normal rates of survival for mice so I wasn't able to tell from the graph whether there is still room for improvement.
Using tetraploid complementation, it is possible to achieve up to 70% of full-term development, which is similar rate of mouse natural conception. And this was before we understood how it works... (read more)
None of the stuff that you suggested has worked for any animal. I'm not saying it's impossible, but it is far harder to achiever compared to the stuff that HAS been demonstrated on mice.
I am PhD in Bio, have an extensive experience with stem cells and gene editing. The idea of human/animal cognitive enhancement is great, but the delivery of gene therapy to adult brains is doomed: first, it's technically challenging if not impossible, second, if we want to achieve a true revolution in cognition, we need to target brain development not already developed brai... (read more)
Using tetraploid complementation, it is possible to achieve up to 70% of full-term development, which is similar rate of mouse natural conception. And this was before we understood how it works... (read more)