The FDA does not provide good guidance on what treatments should be applied in what situations. They approve drugs for a limited set of uses and that's it. Most drugs are applied "off label" which the FDA rules that drug companies specifically cannot comment on -- so not only does the FDA not provide guidance on the most common use for most medications, they actually prevent that guidance from being provided.

You mean the Theranos that is specifically regulated by CLIAA and Medicare which did nothing to stop them until they actually destroyed people's lives?

Or you can buy UL listed ones that work. The UL is a private organization. Which again goes to prove his point.

Why are you nervous to predict the drug doesn't work? Your take seems reasonable and opinion isn't liable so?

Because you can't make money off of it (by definition) so no-one wants to work hard enough on it to make it work. Sort of like communism itself.

There is a difference between normal language evolution and forced changes as a tactic in the post-modern power struggle game. These are usually signaled by the fact they are strongly advocated by a small minority of activists, often not even of the group affected. They are at best generally used to signal allegiance to a certain in-group and "other" less enlightened people. Examples are the term "Latinx" which most Hispanic people dislike. Attempts to rename the homeless a "unhoused" or "people experiencing homelessness" are also noted.

Thanks for the reply

Hi there. I'm confused about the units you are using through the post. You start using milliliters (mL) as a unit when referring to the KCl salt that you were putting on your food. Was it a liquid supplement? If not did you mean milligrams? How did you measure?

Do you have an estimate of the total milligrams or milliequivalents per day?

Thanks for the post!

I am a physician trained in bariatric surgery but do not do it as part of my practice. That being said, on a population level and until the recent introduction of the GLP drugs bariatric surgery is the only thing that actually results in long-term weight loss for morbidly obese people. It does, however, have significant risk of early and late complications and vastly changes behavior, which some people find it hard to deal with. Early complications include leak with about a 2% risk, death with about 1/500 or so, and various and sundry other minor complications that have a risk of about 10%.

I would absolutely undergo sleeve or bypass if my BMI went over 35 with any comorbidities if I did not get adequate results from the new GLP medications, which, in my opinion, should definitely be first line for people without contraindications.