If the mucus still being wet matters for transmission, failing to control (or report?) room humidity sounds like a big deal; that's the difference between objects drying in minutes vs approximately never. Though also hard to square that with dry winter conditions being prime cold and flu season. Something like the virus needs moisture to live but also your mucus (and/or related tissues) needs moisture to work as a barrier at all?
Huh, more questions than answers there. Not a biologist but I've got to think there's an easier way to study the surface transmission part than with live virus. If we're assuming that: the virus is basically inert on surfaces and can't move or divide or do much of note; transmission is just a function of how much intact virus makes it to the recipients tissues; then that should let us factor out studying how a ball of proteins about that size move through the environment from actually infecting people. And there's got to be an easier way ... (read more)
It seems like a catastrophic civilizational failure that we don't have confident common knowledge of how colds spread. There have been a number of studies conducted over the years, but most of those were testing secondary endpoints, like how long viruses would survive on surfaces, or how likely they were to be transmitted to people's fingers after touching contaminated surfaces, etc.
However, a few of them involved rounding up some brave volunteers, deliberately infecting some of them, and then arranging matters so as to test various routes of transmission to uninfected volunteers.
My conclusions from reviewing these studies are:
Fomites
This section may as well be called Gwaltney & Hendley, as they conducted basically all of the studies[2] suggesting that fomites might be a substantial vector of transmission.
Gwaltney et al., 1978 conducted three separate trials, each attempting to test a different method of transmission.
The large particle test[3] had 1 donor and 2-4 recipients sitting around a small table (0.7m diameter). Donors were instructed to talk loudly, sing, cough, and sneeze for the 15-minute period. Everyone wore rubber gloves while in the room. 1[4] out of 12 total recipients were infected.
The small particle test housed donors and recipients (1 or 2 recipients per donor - 6 donors & 10 recipients total) together for 3 successive days and nights in a large, closed room, separated by a double wire-mesh barrier to preclude direct contact. Everyone spent all their time in the common room except when in the adjoining bathrooms, or when the donors were being borrowed to expose other recipient groups in other arms of the experiment.
This resulted in zero infections! It seems like moderately strong evidence to me, and makes me update on small particle transmission being less likely; I don't see obvious ways in which this test fails to replicate relevant real-world conditions.
In the fomite test, "donors deliberately contaminated their hands with nasal secretions as they would when blowing their nose". Then they performed a 10-second handshaking procedure with recipients, both sides wearing surgical masks. Recipients then went to another room and self-inoculated by putting their fingers "on their nasal and conjunctival mucosa as they might under natural conditions", two to three times (then washed their hands).
This infected 11 out of 15 recipients. Ok, if you go directly from a wet handshake to rubbing your eyes, you're in trouble, noted. It's not clear how this generalizes to more realistic[5] patterns of fomite transmission. Do people even shake hands nowadays?
Gwaltney & Hendley, 1982 directly tested fomite transmission via shared surface contact. This lets us screen off the risk of accidentally mistaking unintended aerosol transmission for fomite transmission. To summarize, they had donors blow and/or wipe their noses with their fingers, briefly handle a coffee cup or rub a plastic tile. They then gave those objects to the recipients to touch, and had the recipients put their fingers "in contact with the conjunctival and nasal mucosa" (i.e. rub their eyes or pick their nose).
Twenty minutes passed between donors contaminating the tiles and recipients touching them. (Ten minutes on each side of "either apply disinfectant, or not".) The period of time between the contamination and then handling of the coffee cup handles wasn't specified, sadly.
5 of 10 coffee cup recipients, 9 of 16 unsanitized plastic tile recipients, and 7 of 20 sanitized[6] plastic tile recipients became infected.
This seems like pretty strong evidence that indirect transmission via shared surface contact is possible. My prior on that was very high (especially given the previous study); it would be pretty surprising if it turned out that skin contact was load-bearing here. The self-inoculation procedure seems pretty similar, so we don't get much evidence about how effective this route is under "more realistic" conditions.
I also looked at a couple "secondary metric" studies, just to check whether there was anything very surprising there.
Ansari et al. 1991 tested how much virus survived on both people's fingers and metal disks, when directly applied. tl;dr:
Maybe significant for HPIV-3, but rhinoviruses comprise most "common colds", and those seem to stick around for a while.
Winther et al. 2007 tested two things:
The study didn't test for the last leg, i.e. actual infectivity.
Aerosols
And this section, correspondingly, consists entirely of studies that include Elliot C. Dick as an author.
D’Alessio et al., 1984 ran 3 types of experiments with a total of 33 recipients. I'm really hesitant to draw conclusions from this one, because it had some surprising results that I think represent methodological issues.
The first experiment type had donors and recipients playing cards, talking, and singing together in a room for 2-3 hours. Across two rounds, there were 5 donors and 9 recipients. The researchers claim that none of the recipients were infected with RV55 (which they infected the donors with), but see this footnote to the data table for that experiment:
So who knows, really.
The second experiment type had small groups of donors and recipients sharing dormitory rooms for 12 hours a day, 3 days in a row, and "to decrease the likelihood of transmission by fomites, participants were asked to avoid handling one another's personal items and to use separate bathrooms". There were 11 donors and 11 recipients, with 5 groups of 2 each, and 1 group of 1 each. The results from this experiment are reported as "one infection", but once again:
🤔
The third had donors kissing recipients: "Forty-eight hours after being infected with RV55, four donors kissed five recipients for 1 min. A second group of six donors, similarly infected, kissed 11 recipients for 1.5 min (two 45-sec contacts). Each recipient was kissed only once; the donors and recipients were instructed to use the kissing technique most natural for them." They report only one instance of transmission here (recipient no. 16), with this caveat:
As I said above, the methodology here seems much less careful and the results are substantially sketchier; how likely is it that so many test subjects just happen to coincidentally catch a different cold after being exposed to one in the experimental setting?
Dick et al., 1987 had a very interesting, and substantially more robust, experimental design. The first stage, which they ran 3 times, was sticking 20 guys into a room with 4 tables. 8 of those guys had colds, 12 were healthy - each table took 2 infected and 3 uninfected guys. Half (6) of the uninfected guys wore restraining devices meant to prevent them from touching their faces. In the first of the 3 rounds, this device was a "large, clear plastic collar... worn around the neck and supported by the shoulders".
In the second and third rounds, they wore arm restraints "composed of two halves of an orthopedic arm brace held together at the elbow by a moveable hinge welded so that the brace could bend only between 140°and 180°. Both devices enabled effortless movement of the arms, ensuring normal poker playing but preventing the wearer from touching any part of his face. If any of the restrained recipients needed his nose blown or scratched, assistance was given by a monitor."
They then had them play cards together at these tables for 12 hours. (They also went through quite a bit of effort to prevent accidental contamination during e.g. mealtimes.)
So, across 3 rounds, there were 36 recipients - 18 restrained and 18 unrestrained. 10 of the restrained recipients and 12 of the unrestrained recipients were infected.
They also ran a different, fourth round, where they had 12 uninfected guys play cards using "freshly contaminated object" ("cards, poker chips, and pencils") from infected donors playing other games concurrently, swapping out the objects every hour for maximum freshness. They forced those guys to perform "exaggerated hand-to-nose and facial rubbing, often with conjunctival and nasal mucosal contact" every 15 minutes, because "it seemed the recipients were actively avoiding any contact to their faces". None of those guys were infected.
This seems like substantial evidence that under more "realistic" conditions[9], transmission via fomites is not overwhelmingly likely for RV-16. I'd be more hesitant to update very hard without the fourth round, but they had a bunch of guys spend 12 hours playing cards that had been very recently and actively used by a bunch of sick people, and none of them got sick.
This paragraph was somewhat alarming (bolding mine):
How does one square this with Gwaltney & Hendley, 1982? We don't know how long recipients there waiting after the coffee mug handles were contaminated, but there was a 20 minute window between the plastic tiles being contaminated and the recipients touching them. That's longer than the enforced 15-minute interval for face-touching here. A couple possibilities:
Also, I think this does not do much to distinguish between small particle and large particle transmission, given the table size.
Meschievitz et al., 1984 ran six trials where they housed multiple donors (usually between 5 and 10) with multiple recipients (similar numbers), for varying lengths of time, ranging from 5 hours to ~6.5 days. They report:
Their experiment design, in isolation, doesn't give us much to go on for updating on various methods of transmission. However, this does seem like it lets us reconcile Gwaltney (1978)[11] and Dick (1987)[12] - the longer you're in close contact with someone sick, the more likely it is that they successfully cough onto your eyeball.
Other Factors
There are a couple of important factors that the above analysis doesn't cover, that could substantially change takeaways. Briefly, those are:
Review
Andrup et al., 2023 is a more comprehensive meta-analysis of the existing literature on the subject, which I held off on reading before I conducted my own research and wrote up the above analysis (minus the summary at the top). This is their conclusion:
However, as far as I can tell, the only studies they analyzed which could plausibly support transmission via small particles (distinguished from large particles) were two studies on prisoners from the 60s. In the first one[14], researchers sprayed aerosolized inoculum directly into the subjects' noses via a hand atomizer. In the second one[15], they "received aerosol inoculation by means of a molded rubber face mask attached to a cylindrical chamber containing a continuous flow of aerosol generated by a Collison atomizer". All of the studies that tested conditions more similar to the real world found no transmission via small particle aerosols.
Conclusion
"Large" particle transmission: likely, especially over extended periods of time. (Remember, 10 of 18 experiment subjects were infected within a 12 hour period despite being physically restrained from touching their face with their hands.) "Small" particle transmission: not very likely (maybe even "very unlikely"). Fomite transmission: possible, but the strongest evidence comes from studies that are testing pretty contrived[16] setups, whereas the studies that check more natural conditions don't see very high rates of transmission against the aerosol baseline. My guess is that in practice, fomites are probably not responsible for most adult-to-adult transmission. (I'm much less confident about children.)
Definitely avoid coughing or sneezing into people's faces. Wash your hands before touching your face, if you're taking care of a sick person... but don't forget to use that paper towel to turn the water off, since faucet handles are hotbeds of other people's germs. Face-to-face conversations seem much worse than ambiently hanging out in the same room.
Overall confidence: low. Reasonable people might not agree with my inferences about the likelihood of "natural" transmission via the three transmission methods described and tested by these studies. Might generalize poorly to children. Might depend on details of specific viruses, and I don't think we've done enough research to have meaningful evidence about whether different RVs have very different transmission profiles from each other.
Thanks to Elizabeth van Nostrand and eukaryote for feedback on clarity. Remaining imprecisions are my own.
Like being in the same room as someone for a while.
That I could find!
The authors note:
However, they don't define "large" or "small" particle sizes anywhere.
The study authors note that the "one infected recipient in the large particle aerosol group had had intimate contact with a hand-contact recipient on the evening of the first day of their exposure to the donor." There are some other details here which suggest the study authors think the transmission was probably still the result of the tested transmission route (large particle) rather than via this unintended side-channel, but it does muddy the waters.
I'm more interested in figuring out indirect transmission via shared surfaces (i.e. doorknobs, shared food serving utensils, etc), as well as "survival" time on various surfaces (including one's own fingers).
The study was simultaneously testing the effectiveness of spraying surfaces with a disinfectant. I omit discussion of those results for brevity.
The researchers eluted the virus from the subjects' fingers, and then used some plaque assays to test the eluates (by culturing).
In this study, they used RT-PCR to test for presence of the virus.
Though still exaggerated: "The average number of hand-to-face contacts recorded (186) over a 12-hr period was far in excess of that observed during normal adult behavior [7]: one "nose pick" every 3 hr and one "eye rub" every 2.7 hr."
50% tissue culture infectious dose, which works by progressively diluting a virus sample until a specific dilution infects 50% of separate "wells" of cell culture samples in a "plate" (a collection of wells).
Only 1 out of 12 recipients sitting together at a table with infected donors were infected, despite high-risk activities like talking, singing, sneezing, and coughing.
10 of 18 recipients, restrained in a way that prevented them from touching their faces, were infected from 12 hours of playing cards at the same table as infected donors. (Also 12 of 18 unrestrained recipients.)
https://pmc.ncbi.nlm.nih.gov/articles/PMC7129024/
https://academic.oup.com/aje/article-abstract/81/1/95/167193
https://journals.asm.org/doi/epdf/10.1128/br.30.3.517-529.1966
And fairly pessimal, for the recipients.