A post on difficulty of eliminating malaria using gene drives: "I worked on gene drives for a number of years jointly as a member of George Church and Flaminia Catteruccia’s labs at Harvard. Most of my effort was spent primarily on an idea for an evolutionary stable gene drive, which didn’t work but we learned some stuff, and I developed a sense for the real challenges with gene drives. It’s something that comes up often when I meet new people in the bio community, so this is my attempt at laying out my perspective. I will be upfront and say I haven’t worked in this field since 2019, and though I’ve tried to update my understanding based on 2024 literature, I might have things wrong based on the bleeding edge."