Join Us for the Memory Decoding Journal Club! A collaboration of the Carboncopies Foundation and BPF Aspirational Neuroscience
This time, we’re exploring a new preprint on how engram-to-engram wiring may store information in memory:
“Engram cell connectivity as a mechanism for information encoding and memory function” Authors: Clara Ortega-de San Luis; Maurizio Pezzoli; Esteban Urrieta; Tomás J. Ryan Institutions: Trinity College Dublin (School of Biochemistry & Immunology; Trinity College Institute of Neuroscience); EPFL (Brain Mind Institute); University of Melbourne (Florey Institute); CIFAR
Engram cells are thought to support memory storage and recall—but what exactly carries the specific information of an experience is still debated. This paper tests the hypothesis that information is encoded in the precise synaptic wiring between engram cells, not only in which cells are recruited. The authors track how learning reshapes connectivity across a defined vCA1 → basal amygdala pathway, then probe causality by artificially activating or inhibiting pre- and post-synaptic components. Finally, they identify a PSD-95–mediated plasticity mechanism that influences these connectivity patterns and may support long-term memory stability.
Presented by: Ariel Zeleznikow-Johnston When? Tuesday, March 3, 2026 – 3:00 PM PST | 6:00 PM EST | 11:00 PM UTC Where? Video conference: https://meet.google.com/udr-jcdc-vkp
Join Us for the Memory Decoding Journal Club!
A collaboration of the Carboncopies Foundation and BPF Aspirational Neuroscience
This time, we’re exploring a new preprint on how engram-to-engram wiring may store information in memory:
“Engram cell connectivity as a mechanism for information encoding and memory function”
Authors: Clara Ortega-de San Luis; Maurizio Pezzoli; Esteban Urrieta; Tomás J. Ryan
Institutions: Trinity College Dublin (School of Biochemistry & Immunology; Trinity College Institute of Neuroscience); EPFL (Brain Mind Institute); University of Melbourne (Florey Institute); CIFAR
Engram cells are thought to support memory storage and recall—but what exactly carries the specific information of an experience is still debated. This paper tests the hypothesis that information is encoded in the precise synaptic wiring between engram cells, not only in which cells are recruited. The authors track how learning reshapes connectivity across a defined vCA1 → basal amygdala pathway, then probe causality by artificially activating or inhibiting pre- and post-synaptic components. Finally, they identify a PSD-95–mediated plasticity mechanism that influences these connectivity patterns and may support long-term memory stability.
Presented by: Ariel Zeleznikow-Johnston
When? Tuesday, March 3, 2026 – 3:00 PM PST | 6:00 PM EST | 11:00 PM UTC
Where? Video conference: https://meet.google.com/udr-jcdc-vkp
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#Neuroscience #MemoryResearch #Engrams #SynapticPlasticity #Hippocampus #Amygdala #JournalClub
#Carboncopies #AspirationalNeuroscience