Motivation for posting:

I read Scott's recent article: https://www.astralcodexten.com/p/why-does-ozempic-cure-all-diseases

And it seems to me that scott isn't considering two points:

1. GLP-1s might fix a lot of things because people are metabolically compromised (e.g. literally to the point of having mitochondria that are unable to properly use all respiratory complexes due to an odd selection effect in always-high glucose environments) - Or they might be magic, but as of yet there's no conclusive evidence and a lot of incentives to say "magic"
2. You can always come up with alternative mechanisms for why GLP-1s might work, but we should wait for more studies to be done in basically healthy people before we recommend basically healthy people take them
3. If you are a basically healthy person, especially one that is looks-obsessed or hypochondriac, the risks might outweigh the benefits of GLP-1s... and while nobody is saying the reverse outright, there's a lot of hinting at benefits with no mention of side effects.