Grey Goo Requires AI

And it could be made via some modifications of E.Coli or other simple bacteria, like adding ability to fix nitrogen. It almost happened already during Azolla event.

Neurocryopreservation vs whole-body preservation

A strong argument for brain-only preservation is that by law (in Russia) only skeleton is a body, and the brain is only a tissue sample, so less possible problems if police asks about legal basis.  I did brain-only preservation for my mother, and they returned the upper part of the skull back, and she looked as if nothing happened and she had full christian service in open casket with many people attending – and nobody knows that she is cryopreserved and a possible conflict was avoided. 

Overall numbers won't show the English strain coming

In some states the spread of the British variant will be obvious earlier, and it could be observed as double peak on charts. 

The situation in the UK could be also informative. There are 57K cases today in UK.

Anti-Aging: State of the Art

That is true for therapies which work on damage (SENS). But if we see aging as a process which creates the damages, than it is reasonable to stop it on early age. 

Also, I've seen a recent article "Longevity‐related molecular pathways are subject to midlife “switch” in humans" which implies that many interventions should happen early in life.

Thanks for great post!

Anti-Aging: State of the Art

It is safe enough to be sold OTC, and there are some research which connects with life extension effects. The real problem is that we don't have human tests of its effects on longevity, despite its widespread use. The first study like this will be TAME, which will explore life extension properties of metformin. There are several reasons why such studies are difficult to perform. Firstly, they are costly, but known safe things are non-patentable. Secondly, they need to be very long., and long human studies are especially costly.

Anti-Aging: State of the Art

Unfortunately, it seems that most intervention works before aging actually developed, so we need to give them to younger people, at least before 50.

AI Alignment, Philosophical Pluralism, and the Relevance of Non-Western Philosophy

There is an article which covers similar topics, but only abstract is available: 

African Reasons Why Artificial Intelligence Should Not Maximize Utility


Anti-Aging: State of the Art

There is a problem with most anti-aging interventions: long expected duration of human trials, as results and lack of side effects will be obvious only decades after the start oа such trials. Without trials, FDA will never approve such therapies. 

However, there is a way to increase the speed of trials using biomarkers of aging - or testing of already known to be safe interventions, like vitamin D. But biomarkers need to be calibrated and safe interventions provide only small effects on aging. Thus, it looks like some way to accelerate trials is needed if we want radical solution to aging to 2030. What could it be?

avturchin's Shortform

Glitch in the Matrix: Urban Legend or Evidence of the Simulation? The article is here: https://philpapers.org/rec/TURGIT
In the last decade, an urban legend about “glitches in the matrix” has become popular. As it is typical for urban legends, there is no evidence for most such stories, and the phenomenon could be explained as resulting from hoaxes, creepypasta, coincidence, and different forms of cognitive bias. In addition, the folk understanding of probability does not bear much resemblance to actual probability distributions, resulting in the illusion of improbable events, like the “birthday paradox”. Moreover, many such stories, even if they were true, could not be considered evidence of glitches in a linear-time computer simulation, as the reported “glitches” often assume non-linearity of time and space—like premonitions or changes to the past. Different types of simulations assume different types of glitches; for example, dreams are often very glitchy. Here, we explore the theoretical conditions necessary for such glitches to occur and then create a typology of so-called “GITM” reports. One interesting hypothetical subtype is “viruses in the matrix”, that is, self-replicating units which consume computational resources in a manner similar to transposons in the genome, biological and computer viruses, and memes.


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