Author, The Roots of Progress (rootsofprogress.org). Part-time tech consultant, Our World in Data. Former software engineering manager and tech startup founder.
OP here. I will recuse myself from the conversation about whether this deserves to be in any list or collection. However, on the topic of whether it belongs on LW at all, I'll just note that I was specifically invited by LW admins to cross-post my blog here.
Re air pollution, there's already been significant improvement in wealthier countries, at least in the last ~century:
More info: https://ourworldindata.org/outdoor-air-pollution#the-long-term-decline-of-air-pollution-in-rich-countries
Good point, I skipped wood here. This is an old post, I mention wood in my more recent treatments of this topic.
And good point about reinforcing being an old technique! Another thing I learned about after I wrote this post is wattle & daub.
I'm not a comp bio expert, but the core of @johnswentworth's argument seems to be that “protein shape tells us very little about [protein reactions] without extensive additional simulation”, and “the simulation is expensive in much the same way as the folding problem itself.”
Both true as far as I understand, but that doesn't mean those problems are intractable, any more than protein folding itself was intractable.
So I think you can argue “this doesn't immediately lead to massive practical applications, there are more hard problems to solve”, but not “this isn't a big deal and doesn't really matter” in the long run.
Good question, I don't know. Someone pointed me to this technical description of mRNA technology which I haven't read yet, might see if it answers your question though: https://www.nature.com/articles/nrd.2017.243
Well here are some sources and further reading:
RNA vaccine explainer from Moderna: https://www.youtube.com/watch?v=qJlP91xjvsQ
A longer essay I wrote: https://rootsofprogress.org/smallpox-and-vaccines
Some folks at NYU are doing an interesting project collecting data and case studies on this: Transit Costs Project
Well, I think there are. See this article, especially South Korea: https://www.vox.com/2016/2/29/11132930/nuclear-power-costs-us-france-korea
Hm. Very interesting.
EDIT: I just remembered that I think this is mentioned in The Rise and Fall of American Growth and that it was attributed to an increase in specialization
Yes, @NeuroStats likes to call it “Granger prediction” for this reason