Randomized, Controlled

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D&D.Sci(-Fi) June 2021: The Duel with Earwax

If someone wanted to work on this collaboratively or just let me watch you work for a bit, HMU! I'm an experienced programmer, but fairly inexperienced with data analysis.

Scaling Networks of Trust

It's been about 15 years since I read Samuel Delany's Times Square Red, Times Square Blue, but I read it multiple times and wrote a paper or two which were heavily influenced by it.

This post reminded me of it. You might find it an interesting read. Times Square Red, the second half, is about strong and weak social networks (particularly in urban environments) and how they function.

Just a heads-up: the first half is quite sexually graphic -- it's a pretty explicit memoir of Delany's time in the Times Square porn theaters and the subculture of gay/homosocial sex and relationships that flourished there. It's pretty raunchy : )

What are good resources for gears models of joint health?

standard markers of inflammation, ESR, CRP, etc. Or you could even look for the curve of cortisol response and clotting factors with a venous catheter, I guess. But again, not at all relevant outside of an academic curiosity unless you are training to be an athlet (which is unhealthy and should be avoided).

Are you implying I shouldn't [overly] worry about chronic inflammation? I'm pretty confident there is an inflammatory component here -- icing and voltaran do seem to help. It's been long enough (3 months) that I've started to think about trying a curcumin supplement and/or just cooking with tumeric+black pepper a bunch.

What are good resources for gears models of joint health?

No, it's really very much about your individual body and where you have lacks, you need an in-person trainer to be able to see this and over time as you move more you'll become more aware of your body and be able to say "Ah, it's x area that's too stiff, or activating too much, or that should be working but isn't or whatever"

Thank you for the info! Do you have any thoughts on how to evaluate a trainer's ability to discern this sort of thing? I'm happy to work with trainers and pay for expertise, but my general sense is that standards of research in sports medicine aren't great.

The Apprentice Thread

[Apprentice] I'm interested in this, may be over committed at the moment, but would really enjoy an intro chat.

What are good resources for gears models of joint health?

Stability training [evidence: not good because everyone disagrees what exactly this involves, but basically all physiotherapists are doing some form of stability training so it's obviously useful | overall you can pick a specific older technique and you will get solid evidence, but newer stuff might actually be better, but less tested]

I did a little quick searching for "knee stability training protocol" and.. found a few things that looked pretty obvious. Quads, hams, calves, etc. More or less what I'd expect. I don't suppose you have any secret sauce beyond that?

resistance training 2-3 times a week (the kind where you are in excruciating pain by the end, i.e. proper resistance training not aerobics masquerading as resistance training),

Ie, "train to failure"? If so, I was under the impression that training to failure is now considered less effective/useful.

(e.g. don't look for joint pain after trying a new style of movement, look for proxies in your blood).

I'm not an athlete, but what would the proxies be?

Is the length of the Covid-19 incubation period likely to be affected by whether you are vaccinated?

Thank you for the info dump.

Basically, my real theory is basically to follow my cravings, try to AVOID eating unless I CRAVE some food or drink (and eat half of how much I think I want, then get seconds after 10 minutes if I still wanna), use common sense (liberally sprinkled with evolutionary bullshit), copy the diets of people similar to me who seem successful, and cross my fingers.

This closely accords with my intuition, the only part I haven't been doing is the 10 min cool off for seconds. I'll add that.

Thank you. : )

The Apprentice Thread

[APPRENTICE] I'd like to learn more about investing and finance, to the extent that finance will help me understand investing. My goal in this is primarily being able to manage my own money/investments and ultimately to be able to reach financial independence so that I can work on effective/impactful causes and donate more. I've been reading more about cryptoassets lately, but don't have strong opinions yet about where is best to point my attention in this field.

[MENTOR] I'm a self-taught programmer who's done mostly web-programming (lot of Python, Django, some FE, some JS/node). I'm potentially available for some amount of mentoring in that area.

What are good resources for gears models of joint health?

This has good rather long and I'm out of time, but if you are interested - I could run through a diagnostic process for knee pain.

I haven't had a chance to digest this all, but I'd certainly be interested.

Is the length of the Covid-19 incubation period likely to be affected by whether you are vaccinated?

because even just 1 drink of alcohol wipes out a large percent of your immune cells for hours or days, and then your hematopoietic cells rebuild them at the cost of telomere shorting

Say waaaaaaaaaaaaaaaaaaa?

It's a bit unclear from your context: are you asserting this for everyone or primarily for people who are abusing alcohol?

I do have to say, I've always been pretty confused by the inconclusive evidence that drinking may have some positive health effects. Maybe I just tolerate alcohol less than average, but I've often felt like I was just dosing myself with poison based on one or two drinks and how bleeeech I would generally feel the next morning. There have been a number of times when I've felt like this might be a bad hedonic cost/benefit trade off, but there are a number of beers whose taste I like enough that I haven't really been tempted to just set a blanket no-booze policy.

In your judgement, is a blanket no-booze policy worth considering? (I'm a pretty infrequent drinker currently: a heavy drinking week might see three or four units; most weeks are zero units.)

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