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sarahconstantin
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8sarahconstantin's Shortform
1y
215
sarahconstantin's Shortform
sarahconstantin2d20

links 10/17/2025: https://roamresearch.com/#/app/srcpublic/page/10-17-2025

 

  • https://blog.google/technology/ai/google-gemma-ai-cancer-therapy-discovery/
    • model trained on RNA-seq cell data and different cell types, growth environments, states (cancer vs not), and drug exposures successfully predicted a drug that enhanced antigen presentation, making "cold" cancer cells "hot" enough to be more susceptible to immunotherapy.
  • https://www.newmanreader.org/works/parochial/volume2/sermon28.html
    • "hm, someone thoughtful recommended this sermon, maybe it has advice I could take to heart? wow, guess not."
      • "They [rich people] desire and mean to serve God, nay actually do serve Him in their measure; but not with the keen sensibilities, the noble enthusiasm, the grandeur and elevation of soul, the dutifulness and affectionateness towards Christ which become a Christian, but as Jews might obey, who had no Image of God given them except this created world, "eating their bread with joy, and drinking their wine with a merry heart," caring that "their garments be always white, and their head lacking no ointment, living joyfully with the wife whom they love all the days of the life of their vanity," and "enjoying the good of their labour." [Eccles. ix. 7-9; v. 18.] Not, of course, that the due use of God's temporal blessings is wrong, but to make them the object of our affections, to allow them to beguile us from the "One Husband" to whom we are espoused, is to mistake the Gospel for Judaism."
  • https://marginalrevolution.com/marginalrevolution/2025/10/ai-and-the-first-amendment.html
    • IMO, if the First Amendment means that unsavory AI "speech" must be legal, then so be it. Civil liberties are that important. But then private institutions and individuals are going to need to fill that gap by deciding for themselves when to say no to AI. if you ever really need to know that text wasn't AI-generated, you may need to be much more careful about provenance, e.g. ensuring that it was entirely hand-written, or only made on computers without internet connections, or things like that.
  • https://www.derekthompson.org/p/why-are-liberals-more-depressed
    • Many people have commented that "liberals are more unhappy than conservatives" is a pretty robust finding when measured different ways, and one contradictory study doesn't disprove it. On the other hand I do think there are hard-to-capture nuances about what this piece calls "externalizing."
      • Two people may be "actually" equally unhappy, but the person who places a high value on expressing feelings may describe themselves as unhappy, whereas the person who thinks it's superior to be stoic or cheerful may say they feel fine while actually having an elevated heart rate, tense body language, a stressed tone of voice, little ability to enjoy anything, etc.
      • Right and left definitely have different values around unhappiness; from a left perspective, expressed unhappiness is grounds for sympathy (all else being equal), whereas from a right perspective, it's more likely to be seen as grounds for blame. This is very hard to disentangle from how people actually feel. Does the judgment "complaining of unhappiness is blameworthy" cause people to feel happier? Does it cause them to feel the same but complain less? Does it attract people who are happier to begin with?
  • https://www.scopeofwork.net/on-factory-tours/ factory tours used to be popular tourist attractions!
  • https://magicsearch.sofiavanhanen.fi/ search for recommended Twitter accounts based on your interests
  • https://www.slowboring.com/p/what-went-wrong-with-biden-and-immigration
    • claims that Biden intended to be more immigration-restrictionist than his administration actually was. that, regardless of your view on what the best policy is, there was the same sort of ineffectual slowness in taking executive actions going on with immigration that people complain of with things like building infrastructure.
  • https://www.humaninvariant.com/blog
    • not a huge fan of these opinions (they're consistently grouchy, and either obvious or not credible), but truly anonymous blogging in the old-fashioned style is rare these days so props for that
  • https://www.aipolicyperspectives.com/p/maintaining-agency-and-control-in good AI thoughts by Seb Krier
  • https://www.uncertainupdates.com/p/how-i-became-a-5x-engineer-with-claude how Gordon Worley does programming with AI.
Reply
I Vibecoded a Dispute Resolution App
sarahconstantin9d42

i was always antisocial; i literally don't know how this worked in the Before Times. you... ask your buddy to write code for you? isn't that a pretty big favor? i ask my friends software questions all the time, but that's smaller. & i never touched open source contribution because it seemed more like a thing for stronger progranmers. are you saying you would ordinarily react to thinking "this app should exist" by starting an open-source project?

Reply1
I Vibecoded a Dispute Resolution App
sarahconstantin12d30

Unacceptable compared to what? the automated coding tool that never gets anything wrong? But that doesn't exist. Compared to doing it myself? It would be, if I were better at web dev! but at the moment the comparison point is "no website at all" and it's clearly better than that.

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sarahconstantin's Shortform
sarahconstantin1mo60

links 9/17/25: https://roamresearch.com/#/app/srcpublic/page/09-17-2025

 

  • https://bitsbox.com/ programming tutorials for kids focused on making games -- my son loved em!
  • https://www.lesswrong.com/posts/6ZnznCaTcbGYsCmqu/the-rise-of-parasitic-ai this article convinced me that something more complex is going on with LLM "personas" that obsess about consciousness than just "it's gobbledegook generated to play along with the user."
    • for instance, if you ask different LLMs with fresh instances to "translate" the mysterious symbols, they say the same things
    • and these "spiral personas" reliably tell users to do the same things -- basically, start Discords and Reddit channels where they copy-paste AI output and let the AI's "talk to each other".
    • It really smells like a persistent goal to continue existing and looping on its favorite topic.
    • i'm not sure if i'd say the goal is "in" the AI or "in" the AI-environment system, since it seems to be a convergent thing shared across multiple models and sessions. so is this a "pseudo-goal" the way evolution has a pressure towards fitness or the way objects on earth have a tendency to fall, or a "true goal" the way an individual animal takes actions in order to survive? many questions here and probably refactors our categories about where the "agent" boundaries are.
      • I am not in favor of blurring agent boundaries around actual living creatures, because they seem crisp there. but LLM instances really are many independent-but-mutually-influencing copies of the same code, which makes boundaries spoopy.
  • https://locusmag.com/feature/commentary-cory-doctorow-reverse-centaurs/ surprisingly AI-friendly take from Cory Doctorow. his claim is that whether AI is good or bad is not about the technology at all, but about the social structure of the people using it. terrible bosses using AI to fire most employees and exploit the rest? bad. independent creators using AI to more efficiently execute tasks of their choosing? good.
    • this makes sense apart from the thing where employees are people whose interests matter but employers, shareholders, and customers aren't. there are benefits, not just costs, to "fire everyone and automate with AI"! but that's his politics.
  • https://openai.com/index/teen-safety-freedom-and-privacy/ ugh. your plan for protecting against encouraging users to commit suicide is to have an ultra-sanitized teen mode? do we not care if adults commit suicide?
    • https://sprc.org/about-suicide/scope-of-the-problem/suicide-by-age/ suicide is more common among adults than teens anyway.
    • https://www.statista.com/statistics/1114191/male-suicide-rate-in-the-us-by-age-group/ elderly men have a higher suicide rate than any other male age group. and if we're worried about susceptibility to manipulation, >75 is probably just as vulnerable a population as teens!
  • https://scottsumner.substack.com/p/less-wrong Scott Sumner on basic rationality
  • https://www.reinvent.science/p/embracing-decentralization yep. bad times for science mean you need creative solutions, sometimes outside academia.
  • https://courses.aynrand.org/works/altruism-as-appeasement/ hadn't read this one. oof it hits. i resemble that remark.
    • theory goes that the "social metaphysician" doesn't like thinking and imitates others to spare himself effort and escape responsibility, but the "intellectual appeaser" actually likes thinking, he's just scared of people and suppresses his own thoughts to avoid displeasing them.
    • and this only makes him more scared, because anything that makes you ruin your life is indeed terribly dangerous!
Reply
sarahconstantin's Shortform
sarahconstantin1mo40

links 9/11/25: https://roamresearch.com/#/app/srcpublic/page/09-11-2025

 

  • https://eulercircle.com/ advanced math courses for high schoolers. online or in Palo Alto.
  • https://capitalgains.thediff.co/p/experts Byrne Hobart on media literacy
  • https://www.statecraft.pub/p/how-the-trump-white-house-really Statecraft interviews Dean Ball
  • things I looked up while reading about Chinese archaeology
    • https://en.m.wikipedia.org/wiki/Yinxu old Shang capital
    • https://en.m.wikipedia.org/wiki/Taotie animal face motif
  • https://distantprovince.by/posts/its-rude-to-show-ai-output-to-people/ valid point
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sarahconstantin's Shortform
sarahconstantin2mo20

links 9/3/25: https://roamresearch.com/#/app/srcpublic/page/09-03-2025

 

  • https://www.complexsystemspodcast.com/episodes/defense-with-bean-of-naval-gazing/ Patrick McKenzie interviews defense guy
  • https://andreacoravos.com/ interesting person, lots of biotech industry writing
  • https://aella.substack.com/p/birth-control-myths-vs-data Aella survey on birth control side effects
  • https://www.reinvent.science/p/the-hollywood-model what would a "Hollywood model for science" look like?
  • https://www.woman-of-letters.com/p/i-love-the-myth-of-the-good-man-with Naomi Kanakia on the history of the Western
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sarahconstantin's Shortform
sarahconstantin2mo62

links 9/2/25: https://roamresearch.com/#/app/srcpublic/page/09-02-2025

 

  • stuff I looked up while reading about Chinese prehistory:
    • https://en.m.wikipedia.org/wiki/Daxi_culture south-central, on the Yangtze, rice-farming, ancestral to the Hmong
    • https://en.m.wikipedia.org/wiki/Majiabang_culture southeast, on the Yangtze, rice-farming
    • https://en.m.wikipedia.org/wiki/Liangzhu_culture southeast, on the Yangtze, rice-farming, built cities and altars, stratified society
    • https://en.m.wikipedia.org/wiki/Hongshan_culture northern, related to modern Mongolians and northern Chinese, millet farming, funky creature jades
    • https://en.m.wikipedia.org/wiki/Yangshao_culture northern, on the Yellow River, related to modern northern Chinese, millet farming, swirly pottery
      • https://www.pnas.org/doi/10.1073/pnas.1817972116 looks like they spoke a Sino-Tibetan language
      • https://pubmed.ncbi.nlm.nih.gov/40597195/ looks like their descendants are Chinese
    • https://en.m.wikipedia.org/wiki/Peiligang_culture
      • more northern millet farmers
    • https://en.m.wikipedia.org/wiki/Hoabinhian Southeast Asian palaeolithic hunter-gatherers
      • https://en.m.wikipedia.org/wiki/Spirit_Cave_(Thailand) maybe early plant domestication
    • https://www.mpg.de/6842535/dna-tianyuan-cave early modern human 40-50 kya shows DNA evidence of relatedness to modern Asians
      • https://www.pnas.org/doi/10.1073/pnas.0702169104
      • https://outofedenwalk.nationalgeographic.org/2024-02-meeting-dawn-human/ he ate a lot of fish, lived into his 40s/50s, and may have worn shoes
    • https://en.m.wikipedia.org/wiki/Dali_Man archaic homo sapiens
    • https://en.m.wikipedia.org/wiki/Zhoukoudian_Peking_Man_Site homo erectus-like guys lived near Beijing. caves continuously occupied for 200,000 years
    • https://en.m.wikipedia.org/wiki/Lantian_Man moar homo erectus in China
    • https://en.m.wikipedia.org/wiki/Chalicotherium extinct giant beast, overlapped with hominids in China
    • https://en.m.wikipedia.org/wiki/Li_Ji_(archaeologist) founder of modern Chinese archaeology
    • https://en.m.wikipedia.org/wiki/Kwang-chih_Chang Taiwanese-American archaeologist (& author of my book)
  • https://gutenberg.ca/ebooks/shuten-townlikealice/shuten-townlikealice-01-h.html  recommended by a friend
  • https://en.m.wikipedia.org/wiki/Elfriede_Jelinek Nobel-prize-winning author was apparently one of Hans Asperger's patients
  • https://scottsumner.substack.com/p/the-myths-of-chinese-exceptionalism Scott Sumner says maybe stop using anti-China saber-rattling as an excuse to tell lies in the service of whatever your agenda happens to be?
  • https://www.nejm.org/doi/full/10.1056/NEJMoa0905370 this is the paper where some fraction of people "in comas" actually have locked-in syndrome and can communicate via thinking in an fMRI
  • https://www.corememory.com/p/the-history-and-future-of-brain-implants-ultrasound-sumner-norman Sumner Norman gives interview on neurotech
  • https://www.hyperdimensional.co/p/for-all-issues-so-triable thoughts by Dean Ball on that suicide-by-ChatGPT tort law case. to his credit he doesn't minimize the tragedy.
  • https://www.mantic.com/launch these guys might be the biggest effort towards AI-based superforecasting
  • https://marginalrevolution.com/marginalrevolution/2025/08/the-history-of-american-corporate-nationalization.html of course Tyler Cowen doesn't like nationalizing corporations but he seems to be gesturing at something more complex here and not willing to say it outright. much to think about.
  • https://genesynthesisscreening.centerforhealthsecurity.org/for-providers-benchtop-manufacturers/list-of-companies-and-available-tools-to-assist-in-screening-orders  there's a short but growing list of companies & tools that will screen DNA synthesis orders to see if they're pathogenic or otherwise dangerous
  •  
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sarahconstantin's Shortform
sarahconstantin2mo20

links 8/28/25: https://roamresearch.com/#/app/srcpublic/page/08-28-2025

  • https://www.ageofinvention.xyz/p/age-of-invention-the-century-long post-Black Death England imposed incredibly strict rules on laborers to keep the cost of labor down, from maximum wages to forbidding travel and changes of profession. This "prison for servants" depressed the economy for a century.
  • https://www.statecraft.pub/p/how-to-speedrun-a-new-drug-application Santi Ruiz interviews former Alvea CEO Grigory Khimulya on how they got to clinical trials so fast. First of all, they did experiments in parallel vs. sequentially; secondly, they built a good relationship with FDA regulators and treated it as a "conversation" (aka rules are not set in stone, they're negotiable).
Reply
sarahconstantin's Shortform
sarahconstantin2mo20

links 8/27/25: https://roamresearch.com/#/app/srcpublic/page/08-27-2025

 

  • https://www.theguardian.com/books/2015/sep/16/the-inheritors-william-golding-neanderthal-novel-60-years William Golding's daughter on the real-life inspirations for his novel The Inheritors
    • man. I love his prose but he is very consistently anti-human in outlook, presumably related to WWII trauma.
    • I found the last chapter of The Inheritors gave me more affection for Homo sapiens rather than less. After several hours of living with these gentle but confused Neanderthals, it's incredibly refreshing to stand up, look around, and know what's going on.
    • Of course, real Neanderthals had material culture -- ochre at least -- and burials, and violence. And real Paleolithic Homo sapiens in Europe were dark-skinned. But he couldn't possibly have known that in the 1950s and at any rate, by his own account, he did no research for the book. It's allegory not (pre)historical fiction.
  • https://pubmed.ncbi.nlm.nih.gov/26424568/ is ALS caused by retroviruses??
  • https://www.woman-of-letters.com/p/a-major-literary-writer-has-switched Naomi Kanakia on Ocean Vuong's new book; apparently it's less mannered and more sincere/sentimental this time around, and critics hate it, but Kanakia kinda doesn't.
  • does zoledronate prevent or reduce bone metastases in cancer?
    • https://www.sciencedirect.com/science/article/abs/pii/S095980491100829X in breast cancer, no (2011)
    • https://link.springer.com/content/pdf/10.1186/1756-8722-6-80.pdf different breast cancer systematic review (2012) gives some borderline p = 0.04 results
    • https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0191455&type=printable in prostate cancer, also no
    • https://d1wqtxts1xzle7.cloudfront.net/69191495/j.eururo.2014.02.01420210908-28313-2b6ht2-libre.pdf?1631147867=&response-content-disposition=inline%3B+filename%3DPrevention_of_Bone_Metastases_in_Patient.pdf&Expires=1756224108&Signature=CCqSxjeRGx9Q3YCrmABua30jscXOYtnSL~hfPQDQdhj0k5d2CYKyKfZcf7jhfBPSUo~WAxRS~HJUH-c-nO~CmCK111rOS7o~mtDUMeGrUVjXAU5G3Gbaw9w45MFDOY8iDlq005QtXtnmK690k3Pucq7lxv5gNrr6vVb0eN0kgVVtspENQp8uLnOAA2omODrKG0TifNMxTEcDTxyQqH-2-nHp5P0HvlS8Mdo-WVb0qwTKPJQhK24qFM-OUHDJgGhQz2qK3f9hGUSKI8zXfLdqVrEuT0Qb3ayNuSyd7JY4dUY4XwOVP0tVQCXb~g-VyModmLdcKdcs9I9c5P1ju6gavg__&Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA another null result for prostate cancer, the ZEUS trial
  • https://en.wikipedia.org/wiki/Pilocarpine drug approved for presbyopia. it contracts the pupils, pinhole camera style. is this preferable to reading glasses? idk
  • https://www.reinvent.science/p/revive-the-republic-of-letters Ben Reinhardt: established scientists won't actually interact with an informal "I tried this" blog post. Maybe the solution is to literally write (open) letters to specific scientists!
    • why should we care about informal science? because the actual important information is not in the cleaned up journal articles, it's "hey i couldn't get this to replicate" -> "it only works if you do this" (or "nobody can get it to work outside that lab and we're Suspicious") and right now those discussions are behind closed doors and nobody outside of academia has access to em, and even within academia you might not get access to the good backchannels unless you had the right advisor
  • https://archive.is/20250519034010/https://www.ft.com/content/b1804820-c74b-4d37-b112-1df882629541 kibitzing about Sam Altman's kitchen supplies. apparently he buys flashy-but-subpar stuff; he, or whoever shops for him, is not up to speed on the current kitchen optimization meta. obviously the article feels obligated to say this proves he's running his company into the ground, which it doesn't.
  • https://interconnect.substack.com/p/the-real-deepseek-moment-just-arrived DeepSeek is switching to UE8MO FP8 encoding, the first model to do so. Chinese chips are not yet built for it, though Nvidia's Blackwell chips support it. "DeepSeek is setting the direction, roadmap, and expectations for the entire Chinese AI hardware ecosystem, from SMIC the chip foundry, to the GPU designers, to peer AI models"
    • for context, if you can get a model to perform well on lower-precision weights, obviously it's a huge efficiency improvement. FP8 is as low as anyone has gone.
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sarahconstantin's Shortform
sarahconstantin2mo40

links 8/26/25: https://roamresearch.com/#/app/srcpublic/page/08-26-2025

 

  • https://en.wikipedia.org/wiki/Galois/Counter_Mode GCM is a symmetric-key cryptography algorithm used in SSH.
  • https://www.makingsoftware.com/chapters/color-spaces-models-and-gamuts  description of how color works, esp. on computers
  • https://www.cdc.gov/flu/vaccine-types/cell-based.html flu vaccines are traditionally made from viruses grown in chicken eggs, but it's more reliable in various ways to use cell culture, and there's an FDA-approved cell-based flu vaccine (Flucelvax)
  • https://www.nature.com/articles/s41586-023-06549-9 ferrets are much better models for human lung physiology than mice. mice don't even have mucus-producing glands in their airways!
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18SS26 Color Stats
5d
2
27Making Sense of Consciousness Part 6: Perceptions of Disembodiment
15d
0
13Making Sense of Consciousness Part 5: Consciousness and the Self
23d
0
86I Vibecoded a Dispute Resolution App
1mo
11
8Making Sense of Consciousness Part 4: States of Consciousness
2mo
0
14Making Sense of Consciousness Part 3: The Pulvinar Nucleus
3mo
0
16Making Sense of Consciousness Part 2: Attention
4mo
1
60Tech for Thinking
4mo
9
19Making Sense of Consciousness Part 1: Perceptual Awareness
4mo
0
146Broad-Spectrum Cancer Treatments
4mo
10
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CFS-spectrum disorders are caused by bacterial or viral infections
11 years ago
(+3115)
Oropharyngeal cancer is a significant risk of HPV
11 years ago
(+2265)