I agree. It could be all shut down in a minute, or the FDA might have other priorities. 

Regarding the concern that oral vaccines could trigger allergies -- you're not the only person who has voiced that concern.  Based on my crude understanding from talking with ChatGPT briefly about this, if the vaccine targets M cells (which this one is hypothesized to do), it induces a systemic and possibly mucousal immune response, not the type of IgE mediated response that causes allergies to develop. 

I think what you're saying about vaccine hesitancy is the conventional thinking, and it's not wrong -- there is indeed a large partisan gap. I guess what I'm saying is that decentralized development of yeast-based vaccines should reduce hesitancy on the margin, given the extreme safety of subunit vaccines in general. 

@Raemon I think there's a slight bug with the calendar (https://www.waypoint.lighthaven.space/e/solstice-season/schedule For me, it shows the Before Party and Speed Friending under Thurs Dec 4th and the Solstice Events under Friday Dec 5th (they are shifted back a day). (The dates on the events are correct, it is just the calendar display that is off). This might be a fluke due to my local browser environment, though. 

 

I see it, and I can log in.

OK, I admit there was important subtext that I missed here. Mea culpa.

I've never heard of cyclic peptides. But I suppose it is possible. 

Actually the HPLC study we cite talks about a similar possibility - they say the observed effects may be due to "cryptic peptides", perhaps created by the lysing of larger proteins and peptides. It just seems very unlikely to me. To me, based on my metascience research, it's a it easier to believe that the published literature is just plain wrong. Check out the HPLC paper - it's he only we found doing that sort of analysis but it's very detailed (https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/abs/10.1002/dta.1817). 

In the case of Bryan Johnson he injected it in his glute. Others inject in the thigh (there's a how-to video about this on YouTube). Apparently some biohackers online think that by injecting in the shoulder more will reach the brain, because the shoulder is closer to the head, according to a podcast I listened to LOL (the podcaster agreed this made a lot of sense). 

Uh this is kinda embarrassing but I just didn't really read it at all honestly.. 

Q: when was prion disease discovered

A: "Prion disease was first recognized as a distinct category of neurodegenerative disorders in the 1980s, though the groundwork for its discovery was laid earlier.

Key milestones in the discovery of prion diseases include:

1. 1920s: Creutzfeldt-Jakob Disease (CJD) was first described by Hans Gerhard Creutzfeldt and Alfons Maria Jakob.
2. 1950s: Carleton Gajdusek began studying kuru, a disease affecting the Fore people of Papua New Guinea.
3. 1960s: Gajdusek demonstrated that kuru could be transmitted to chimpanzees, suggesting an infectious etiology.
4. 1982: Stanley Prusiner coined the term "prion" (for proteinaceous infectious particle) and proposed the protein-only hypothesis for these infectious agents.
5. 1997: Prusiner was awarded the Nobel Prize in Physiology or Medicine for his work on prions.

The concept of prions as the causative agents of these diseases was revolutionary because it challenged the central dogma of biology, suggesting that proteins alone, without nucleic acids, could be infectious.

Would you like me to elaborate on any specific aspect of prion disease discovery?"
 

You have an eagle eye Carl!... I actually asked Claude (the AI) about this when I was writing it, but I was very sloppy and didn't read Claude's answer carefully. Just fixed it. I should be more careful..

Great, I look forward to meeting you there!