I always feel like this question is missing something, because it forgets the biggest cost for evolution: deploying the algorithms in the real world and seeing what effects they have.
That is, even if you had all the compute necessary to simulate human brains for all of evolutionary time, you would also need to figure out the effects of the brains on the real world in order to know their usefulness in practice. Doing this directly requires compute on the order of magnitude of the real world, though obviously in practice a lot of this can be optimized away.
I’m looking for estimates of the total compute available to evolution:
Total number of cell divisions
Total number of times a DNA nucleotide was transcribed to RNA
Total number of times an RNA codon was translated to an amino acid
Total number of base pairs in all genomes
Total entropy of the set of all genomes
I’d like to identify other significant sources of compute available to evolution (epigenome? lateral gene transfer? interspecies communication?) and how to quantify them.
I’m looking for estimates of total compute over all 4 billion years of Earth life, and also how compute varied with time.
Grateful for any leads!