Here's another interim report on the longitudinal effects of CR on rhesus monkeys, this one a bit more recent (2009) than the one linked in the OP. From the abstract:

We report findings of a 20-year longitudinal adult-onset CR study in rhesus monkeys aimed at filling this critical gap in aging research. In a population of rhesus macaques maintained at the Wisconsin National Primate Research Center, moderate CR lowered the incidence of aging-related deaths. At the time point reported 50% of control fed animals survived compared with 80% survival of CR animals. Further, CR delayed the onset of age-associated pathologies. Specifically, CR reduced the incidence of diabetes, cancer, cardiovascular disease, and brain atrophy. These data demonstrate that CR slows aging in a primate species.

Life Extension through Diet Modification

by Caerbannog 1 min read16th May 201131 comments


Life extension is a relevant topic here, and I was wondering if people are aware of the apparently life-extending effects of calorie restriction (CR) and intermittent fasting (IF). To the extent of my knowledge, this is the best method using currently realized technology that has shown repeated and significant life-extension benefits.

Studies show that reducing calories by 20% to 40% from ad libitum feeding (but maintaining the supply of required protein and micro-nutrients) gives improvements in markers related to aging, and extends life span in rodents and other organisms.

Other rodent studies have also shown similar results in subjects which were kept on various intermittent fasting schedules. Rats that were fed only on alternating days gained up to 25% lifespan (see Table 2).

The benefits of IF are seen even if the total calorie intake is the same as in ad libitum subjects.

There are ongoing full-lifespan studies in rhesus macaques to test the effects in primates, but none of these studies have completed. This abstract of the interim results appears promising, though.

Studies of CR and IF on humans have shown effects consistent with reduced mortality, including:
- Improved triglyceride profiles (a marker for heart disease)
- Increased insulin sensitivity
- Reduced cell proliferation (a marker for cancer)

Generally, these diet modifications appear to not just extend life span, but improve the quality of life too. In aged subjects they improve things like: muscle mass, cognition, energy, appearance, and activity level.

Have people heard about this or tried it? If you are trying to maximize your chance of surviving to the point that technology can lengthen lifespan indefinitely, it seems like something worth exploring.

I tried an IF schedule for about 6 months during 2010. I followed a schedule of 3 x ~thirty hour fasts every 7 days and found it somewhat tolerable. I exercise regularly and found that exercising on the non-fasting days was not a problem. I'm thinking of starting up such a schedule again.