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What are some strategies you use to "reduce the hit" when you're about to take in potentially bad news? This is important b/c it's sometimes important to face up "bad news" earlier rather than later, and there is social loss in some people not being able to face it until it's too late, esp b/c some kinds of "bad news" aren't as incorrigible as they may initially appear (just that you need out-of-distribution strategies to make the proper amends)

[some examples of bad news: irreversible data loss, cancer diagnosis, elevated epigenetic age, loss of important friend, someone overpromised and underdelivered on you and that affects many of the promises you made]

[as AGI timelines come "nearer", "bad news" may come at faster frequencies, but OOD ways to solve them may also come faster]

[sometimes you can ask yourself "how much wealth would you need to take in any bad news"]. Wealth is not fully-completely interchangeable with youth/intelligence/universal social acceptance, but it DEFINITELY has potential for tipping the needle..

Generally interesting people I wish more people would appreciate

Arthur Jiuliani (see his medium)/Adam Safron/Yohan John

Michael Woodley (kind of)

Jeremy Hadfield (

Benjamin Anderson (and their discord)

some neurofeedback peole (still TRYING THIS OUT, the S/N ratio might not be high, but finding the right person alone can make it super-worth it). Need to try LENS neurofeedback (money for this would be helpful btw)

Stephen Frey (undersells himself)

SOME quantified-self'ers

MAYBES: (on brain organoids and autism), Bobby Azarian,


Interesting LessWrong people


matolcsid (infra-bayesianism I could never understand) (another gwern! calls himself midwit) Ad more interested in neurotech

Ege Erdil (gaspode, he has SO MUCH taste)

p.b. (blog @ ). Janus likes him a lot

Matthew Barnett

Jacob Cannell

Interesting links:

Are exotic computing paradigms (ECPs) pro-alignment?


They are orthogonal to the "scale is all you need" people, and the "scale is all you need" thesis is the hardest for alignment/interpretability

some examples of alternatives:, Normal Computing,, computing-related thiel fellows (eg Thomas Sohmers, Tapa Ghosh)

[this is also how to get into neglectedness again, which EA adopted as a principle but recently forgot]

from Charles Rosenbauer:

This is neat, but this does little to nothing to optimize non-AI compute. Modern CPUs are insanely wasteful with transistors, plenty of room for multiple orders of magnitude of optimization there. This is only a fraction of the future of physics-optimized compute.

Using size-1 piksters makes you really aware of all the subtle noise that your hidden plaque is gives your mind (I noticed they cleared up plaque un-reachable by floss+waterpiks+electric toothbrushes.. the first step to alignment/a faithful computation is reducing unnecessary noise (you notice this easily on microdoses of weed/psychedelics)

It's a pareto-efficient improvement to give all alignment researchers piksters to eliminate this source of noise (align the aligners first - reducing unnecessary noise is always the first step to alignment [and near-term tFUS is also a means to reduce noise]). I know that one of the alignment offices had a lot of "freebies" that anyone could use - so piksters should be one of the useable freebies.


Random content I'm reading (could be important)
Natalia Goriounova – Research output — Vrije Universiteit Amsterdam
Evolution of cortical neurons supporting human cognition: Trends in Cognitive Sciences
Verbal and General IQ Associate with Supragranular Layer Thickness and Cell Properties of the Left Temporal Cortex | Cerebral Cortex | Oxford Academic
Frontiers | Genes, Cells and Brain Areas of Intelligence
Dendritic and Axonal Architecture of Individual Pyramidal Neurons across Layers of Adult Human Neocortex | Cerebral Cortex | Oxford Academic
Strong and reliable synaptic communication between pyramidal neurons in adult human cerebral cortex | Cerebral Cortex | Oxford Academic
Genes associated with cognitive ability and HAR show overlapping expression patterns in human cortical neuron types | Nature Communications
Human neocortical expansion involves glutamatergic neuron diversification | Nature
Genes associated with cognitive ability and HAR show overlapping expression patterns in human cortical neuron types - PMC
Dr. Hermann Cuntz | Ernst Strüngmann Institute (ESI) for Neuroscience
A general principle of dendritic constancy: A neuron’s size- and shape-invariant excitability: Neuron
A scaling law derived from optimal dendritic wiring | PNAS
Dr. Hermann Cuntz — 3R Symposium
‪Hermann Cuntz‬ - ‪Google Scholar‬
Topology recapitulates ontogeny of dendritic arbors | bioRxiv
Hermann Cuntz - homepage
Skewed distribution of spines is independent of presynaptic transmitter release and synaptic plasticity and emerges early during adult neurogenesis | bioRxiv
Optimality, evolutionary trade-offs, Pareto theory and degeneracy in neuronal modeling
A general principle of dendritic constancy – a neuron’s size and shape invariant excitability | bioRxiv
Excess Neuronal Branching Allows for Local Innervation of Specific Dendritic Compartments in Mature Cortex | Cerebral Cortex | Oxford Academic

Optimal Current Transfer in Dendrites - PMC
Pyramidal Neurons in Different Cortical Layers Exhibit Distinct Dynamics and Plasticity of Apical Dendritic Spines - PMC
Dendritic Spikes in Apical Dendrites of Neocortical Layer 2/3 Pyramidal Neurons - PMC
Branching morphology determines signal propagation dynamics in neurons | Scientific Reports
Diversity amongst human cortical pyramidal neurons revealed via their sag currents and frequency preferences | Nature Communications
Cell-type specific innervation of cortical pyramidal cells at their apical dendrites | eLife
Dendritic action potentials and computation in human layer 2/3 cortical neurons | Science
Biological complexity facilitates tuning of the neuronal parameter space | PLOS Computational Biology
2023 Neuropixels and OpenScope Workshop - Allen Institute
Extracellular Vesicles from Stem Cells Reverse Senescence
Classification of electrophysiological and morphological types in mouse visual cortex - PMC
Human cortical expansion involves diversification and specialization of supragranular intratelencephalic-projecting neurons | bioRxiv
sanbomics_scripts/RNAseq_method_comparison at main · mousepixels/sanbomics_scripts · GitHub
Introducing the Allen Brain Cell Atlas! - How To / Allen Brain Cell (ABC) Atlas - Allen Brain Map Community Forum
ABC Atlas - Mouse Whole Brain
ABC Atlas User Guide: Tools - How To / Allen Brain Cell (ABC) Atlas - Allen Brain Map Community Forum
Overview :: Allen Brain Atlas: Cell Types
Synaptic Physiology Methods: Experimental Stimuli -
Synaptic Physiology Methods: Cell Classification -
Synaptic Physiology Methods: Synapse Characterization -
Matrix Analyzer — aisynphys documentation
Matrix Analyzer — aisynphys documentation
Synaptic Physiology Methods: Synapse Characterization -
The Genetic Geography of the Brain :: Allen Institute for Brain Science
Data Catalog for Allen Institute's Brain Knowledge Platform
Overview :: Allen Brain Atlas: Cell Types
How to download raw data from Neuropixels public datasets - How To / Brain Knowledge Platform - Allen Brain Map Community Forum
New signaling mechanism in catecholaminergic neurons - OpenScope - Allen Brain Map Community Forum
Dendritic action potentials and computation in human layer 2/3 cortical neurons | Science
Dissecting Sholl Analysis into Its Functional Components - ScienceDirect
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