RT-LAMP is the right way to scale diagnostic testing for the coronavirus

by Kevin1 min read4th Aug 20207 comments

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CoronavirusPracticalWorld Optimization
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RT-LAMP is the right way to scale diagnostic testing for the coronavirus

by Kevin Fischer

kfischer $& gmail *( com

RT-LAMP compared to RT-PCR is a less versatile and more recently invented laboratory technique. LAMP is more suited to actual diagnostic testing at scale than PCR but never became industry standard despite its demonstrated superiority. Labcorp/Quest/One Medical use PCR for their coronavirus diagnostic tests and they currently have delays as long as two weeks for issuing results which is totally unacceptable for fighting this pandemic. Color in San Francisco has one of few widely available RT-LAMP tests for the coronavirus and they generally give results back in one to two business days and are not bottlenecked by laboratory procedure.

An open access RT-LAMP coronavirus diagnostic toolkit was published at the end of July and I believe presents a solution to scaling diagnostic testing to where it needs to be. A rapid, highly sensitive and open-access SARS-CoV-2 detection assay for laboratory and home testing

What steps can we take to help national testing capacity switch to RT-LAMP instead of RT-PCR? There are parallel approaches here -- bottom up development suggests distributed citizen science RT-LAMP labs to fill in gaps in testing capacity, top down distribution suggests convincing the major industry players to devote resources to switching to RT-LAMP over RT-PCR. I'm going to take the bottom up approach; can anyone else figure out how to help Quest and Labcorp switch over to the superior testing method?

Does anyone else want to set up their own RT-LAMP operation? I'm going to give it a try and will write a guide on what to buy once we're operational. One of my business partners was an innovator in LAMP primer design over ten years ago and we still own the lab equipment needed for the simple procedure. Presumably as non FDA approved citizen science it will have to be "for research only" and not for diagnostic testing purposes but it's possible the FDA is being cooperative and that actual FDA licenses could be issued on a timeframe that is reasonable.

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