Many older pieces of once recognised scientific literature are now being deemed unreliable due to small sample bias. An increasing amount of meta-analyses are identifying unreliable fields of study, citing lack of reproducibility in larger sample sizes. It seems likely that we will face increasingly difficult ethical questions about large data collection as academicians attempt to check or re-verify their past claims with larger samples. Do we expect academic institutions to be put under pressure to ignore data-ethics in the future in an effort to correct for small sample bias?