Let's assume we learn how to "do" alignment.
I am beginning to believe that respect for human self-determination is the only safe alignment target.
Human value systems are highly culture bound and vary vastly even by individual.
There are very few universal taboos and even fewer things that everyone wants.
If an all-powerful AI system is completely aligned with, say, the western worldview, then it may seem like a tyrant to other people who lead sufficiently different lives.
The only reasonable solution is to respect individual difference and refuse to override human choices or values (within limits - if your style is murder obviously that can't fly).
We have plenty of precedents in pop culture and politics: the "pursuit of happiness" in democratic liberalism, the "prime directive" from Star Trek, our cultural aversions to tactics that rob people of self-determination, like brainwashing, torture or coercion.