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sarahconstantin's Shortform

by sarahconstantin

1st Oct 2024

1 min read

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links 1/11/26: https://roamresearch.com/#/app/srcpublic/page/01-11-2026

https://www.science.org/doi/full/10.1126/sciadv.aaw7243 TRPM7 is involved in mechanosensing
- https://karger.com/cpb/article-abstract/19/1-4/1/207934/Direct-Mechano-Stress-Sensitivity-of-TRPM7-Channel
https://link.springer.com/article/10.1007/s12032-017-0987-1 TRPM7 is involved in the epithelial-mesenchymal transition in multiple tumor types
- https://journals.sagepub.com/doi/full/10.3233/CBM-190666
- https://aacrjournals.org/cancerres/article/72/16/4250/575870/TRPM7-Is-Required-for-Breast-Tumor-Cell
- https://www.sciencedirect.com/science/article/pii/S0006295223004483
pharmacologically targeting TRPM7 https://www.nature.com/articles/s41467-023-38362-3
DRP1 and mitochondrial fission in cancer https://www.sciencedirect.com/science/article/abs/pii/S0304419X25001957
DNML1 in cancer https://pmc.ncbi.nlm.nih.gov/articles/PMC11540555/
the anti-apoptotic protein FLIP as a cancer target https://febs.onlinelibrary.wiley.com/doi/pdfdirect/10.1111/febs.14523
- https://www.tandfonline.com/doi/full/10.2147/JIR.S519885
- https://www.tandfonline.com/doi/abs/10.1517/14728222.2013.736499
GUK1 and cancer: https://pmc.ncbi.nlm.nih.gov/articles/PMC12148050/
ELL, involved in the elongation phase in transcription, in cancer: https://www.nature.com/articles/nrc2915
SEPHS2 & selenium metabolism in cancer: https://www.sciencedirect.com/science/article/pii/S0006497118585554
- https://link.springer.com/article/10.1007/s00109-025-02563-8
- https://www.nature.com/articles/s42255-020-0224-7
- https://www.nature.com/articles/s41598-019-52718-0
trial of transferrin receptor drug in cancer: https://ashpublications.org/blood/article/144/Supplement%201/1496/531990/Results-of-a-Phase-1-First-in-Human-Study-of-INA03
- more on transferrin & cancer: https://www.sciencedirect.com/science/article/abs/pii/S0304416511001826
NMT1, myristoylation, and cancer: https://www.nature.com/articles/s41598-025-13529-8
- and phase 1 trial of drug with this target: https://link.springer.com/article/10.1007/s10637-024-01448-w
ADSL and cancer
- https://onlinelibrary.wiley.com/doi/pdf/10.1002/hep.31685
PH5A and cancer: https://www.nature.com/articles/s41598-023-44899-6
- https://link.springer.com/content/pdf/10.1186/s12885-024-12620-z.pdf
- https://link.springer.com/content/pdf/10.1186/s12967-022-03821-w.pdf
YRDC and cancer: https://onlinelibrary.wiley.com/doi/full/10.1002/cnr2.70325
- https://www.nature.com/articles/s43018-024-00748-7
https://platform.opentargets.org/ Open Targets Platform, info about many drug targets
https://depmap.org/portal/ DepMap, cancer dependency database
https://www.hyperdimensional.co/p/among-the-agents how Dean Ball uses Claude Code
https://marginalrevolution.com/marginalrevolution/2026/01/the-tyranny-of-the-complainers.html most complaints to government agencies come from a few very active complainers
https://x.com/mollycantillon/status/2008918474006122936?s=20 account (AI-written?) of how someone uses Claude Code for everything. seems potentially appealing
https://www.alexkesin.com/p/a-better-proxy-than-the-rat-and-dog foundation models for toxicology
https://www.asimov.press/p/research-forms metascience
https://archive.ph/20260108173745/https://www.washingtonpost.com/opinions/2026/01/07/ice-minneapolis-shooting-deportaitons-escalation/ this is scary
https://backofmind.substack.com/p/the-myth-of-merit-in-the-managerial this is probably the best defense of affirmative action -- 'you weren't that good at picking the best anyway, it's mostly biases and vibes, so you may as well decide to correct historical inequities'. i think even to the extent this is true you could argue that the policies actually enacted were unwise, but i do think it's a point worth addressing.