links 02/27/25: https://roamresearch.com/#/app/srcpublic/page/02-27-2025

• https://blog.sentinel-team.org/p/sentinel-minutes-for-week-82025 blog of Sentinel, a team of forecasters concerned about catastrophic risks; might be a good news digest for straightforward politics/war/etc
• https://eristicstest.com/ everyone's favorite new personality test
• https://benexdict.io/p/empathy-hardware Benedict Hsieh personal essay
• https://www.shinzen.org/resources/articles/ Shinzen Young on meditation
• https://www.ben-evans.com/benedictevans/2025/2/17/the-deep-research-problem OpenAI's Deep Research spot-check; it's error prone. sources don't always say what the bot says they say.
• https://www.nature.com/articles/s41586-024-08508-4 is this a mRNA cancer vaccine that works? on pancreatic cancer???
  • not so much. this is examining the difference in survival between vaccine responders and nonresponders. It's substantial! but only 8/16 treated patients responded. not clear how it stacks up to other pancreatic cancer treatments.
  • but there are lovely single-cell sequencing techniques to see that the vaccine can induce long-lived T cells
• endometriosis only occurs spontaneously in primates
  • https://www.sciencedirect.com/science/article/abs/pii/S0021997512000072 mandrill
  • https://pb.copernicus.org/articles/4/77/2017/ rhesus monkey
  • https://academic.oup.com/humrep/article-abstract/27/8/2341/712472 olive baboon (this one is induced)
  • https://academic.oup.com/humrep/article-abstract/10/3/558/648290#google_vignette baboons with endometriosis have reduced NK activity
  • https://academic.oup.com/humrep/article-abstract/22/1/272/2939374 it can get into the colon in baboons
  • https://academic.oup.com/humrep/article-abstract/11/9/2022/616104 baboons with endometriosis have more retrograde menstruation (but not all baboons with retrograde menstruation get endometriosis)
  •  
• what works on endometriosis in primate studies?
  • https://www.sciencedirect.com/science/article/abs/pii/S1642431X17302498 Icon immunoconjugate
  • https://academic.oup.com/endo/article-abstract/151/4/1846/2456726 pioglitazone
  • https://academic.oup.com/biolreprod/article-abstract/97/1/32/3869077 simvastatin
  • https://www.sciencedirect.com/science/article/pii/S0015028212024338 aromatase inhibitors
• can you selectively kill ectopic endometrial cells in endometriosis?
  • https://journals.sagepub.com/doi/abs/10.1177/1933719113485298 the endometrial stromal cells are CD10+
    • more on this: https://en.wikipedia.org/wiki/Neprilysin
  • https://link.springer.com/article/10.1007/s10815-023-02772-5 yes they're thinking about cell therapies
• https://www.publicbenefitinnovationfund.org/ Public Benefit Innovation Fund, accepting applications for AI projects that benefit social services
•