links 11/24/25: https://roamresearch.com/#/app/srcpublic/page/11-24-2025

• https://writetobrain.com/olfactory induced smells with transcranial ultrasound
• https://www.biorxiv.org/content/10.1101/2025.09.02.673859v1.full.pdf looks like bad news for the "it's the macrophages, stupid" hypothesis; put aged microglia in young brains and they look like young ones, put young microglia in aged brains and they look like old ones (transcriptionally and morphologically.)
  • it may be "the NK cells, stupid"? if you deplete NK cells from the cerebellum, cerebellar microglia don't get the characteristic age-related interferon signaling.
• https://www.lesswrong.com/posts/apHWSGDiydv3ivmg6/varieties-of-doom JD Pressman explains what he actually thinks will happen with AI
• https://www.lesswrong.com/posts/LaWmoy4s2DLe9u2zq/llm-chatbots-have-half-of-the-kinds-of-consciousness-that Andrew Critch is confident that chatbots introspect, have purposes, have awareness of awareness and perception of perception and memory of memory, have symbol grounding, etc.
  • i confidently disagree, but it would be hard to prove it.

• https://www.untillabs.com/blog/glass-not-ice Until lays out how they intend to improve vitrification for reversible organ preservation (and ultimately preserving whole people).

  • i'd need a lot more physics/chemistry knowledge to have much sense of how feasible this is.