links 3/25/25: https://roamresearch.com/#/app/srcpublic/page/03-25-2025

• low dose aripiprazole papers
  • https://www.psychiatrist.com/pcc/four-cases-chronic-pain-improved-dramatically-following/
    • 4 cases of chronic pain responding to 2mg/day aripiprazole
  • https://journals.sagepub.com/doi/abs/10.1345/aph.1R387
    • torsades de pointes after 5 days on 2.5 mg. (pt had diabetes, hypertension, and stroke history though)
• https://en.m.wikipedia.org/wiki/Polyethylene_glycol
  • ethylene glycol is antifreeze. many of them stacked together is polyethylene glycol, which is Miralax.
    • so why is antifreeze toxic but PEG not?
      • https://claude.ai/share/17d8e7b4-ffd5-4c96-9ca2-fe71c69d828a because the toxicity of ethylene glycol actually comes from the metabolites when it's broken down by alcohol dehydrogenase. if you make a big polymer of PEG, ADH no longer metabolizes it, so it passes through the digestive system harmlessly.
• https://www.thenewatlantis.com/publications/will-anyone-vote-for-abundance
  • yeah everybody reasonable likes Good Things, but in real life we don't have a Good Things party, we have Republicans and Democrats.
• https://thehumanist.com/magazine/fall-2024/features/the-distinction-between-imaginary-science-and-magic Ted Chiang's categorization seems pretty much right; science fiction or "imaginary science" is about processes in an impersonal universe, whereas magic & fantasy are about a universe that relates to people the way people relate to each other.
• https://en.m.wikipedia.org/wiki/Imipramine
  • did we have antidepressants in the 1950's? yes. came out 1957.